Cerebellar parvocellular modules

项目摘要 小脑与许多神经和神经精神疾病有关， 从运动缺陷如共济失调、震颤和不平衡到自闭症， 精神分裂症和冲动我们不知道为什么有些小脑功能障碍的患者 主要经历运动症状，而其他人则患有情绪失调和心理健康 挑战在这个提议中，我们研究了负责不同的神经回路。 小脑运动和非运动功能障碍。结合严格的解剖学方法， 包括专门的病毒回路追踪载体， 连接，这项研究将测试的假设，专门类型的小脑输出神经元 与小脑相关的各种疾病有着不同的关系。 这些实验目标的实现将产生关于大脑的重要新信息- 不同类型的小脑输出神经元之间的广泛连接， 为患有各种运动和运动障碍的患者开发新的诊断和治疗策略 神经精神障碍

Project Summary The cerebellum has been implicated in a remarkable number of neurological and neuropsychiatric disorders that range from motoric deficits such as ataxia, tremor, and disequilibrium to autism, schizophrenia, and impulsivity. We do not know why some patients with dysfunction in the cerebellum experience primarily motoric symptoms while others suffer from dysregulated mood and mental health challenges. In this proposal, we examine the specific neural circuits that are responsible for diverse cerebellar motoric and non-motoric dysfunctions. Using a combination of rigorous anatomical methods, including specialized viral circuit tracing vectors that provide new information about brainwide neuronal connections, this research will test the hypothesis that specialized types of cerebellar output neurons are differentially responsible for the diverse disorders associated with the cerebellum. Accomplishments of these experimental goals will generate important new information about the brain- wide connections made by different types of cerebellar output neurons which will enable the development of new diagnostic and therapeutic strategies for patients with a wide range of motoric and neuropsychiatric disorders.