HyperProbe: Transforming brain surgery by advancing functional-guided neuronavigational imaging

HyperProbe：通过推进功能引导神经导航成像来改变脑外科手术

• 批准号: 10048387
• 金额: $ 66.71万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10048387
• 关键词: HyperProbe; Transforming; brain; surgery; advancing

In recent years, through the advancement of imaging technologies (such as MRI, PET, CT, among others) clinical localisation of lesions of the central nervous system (CNS) pre-surgery has made possible for neurosurgeons to plan and navigate away from functional brain locations when removing tumours. However, neuronavigation in the surgical management of brain tumours remains a significant challenge, due to the inability to maintain accurate spatial information of lesioned and non-lesioned locations intraoperatively. To answer this challenge, we have put together a team of engineers, physicists, data scientists and neurosurgeons to develop an innovative, all-optical intraoperative imaging system based on (i) hyperspectral imaging (HSI) for rapid, multi wavelength spectral acquisition, and (ii) artificial intelligence (AI) for image reconstruction and molecular fingerprint recognition. Our intraoperative HSI system (HyperProbe) will (1) map, monitor and quantify biomolecules of interest; (2) be handheld and user-friendly; (3) apply AI-based methods for the reconstruction of spectral images, the analysis of spatio-spectral data and the development and quantification of novel biomarkers. We will validate the developed capacity in phantoms, in vivo against gold standard modalities in neuronavigational imaging, and finally provide proof of principle during brain tumour surgery. HyperProbe aims at providing functional and structural information on biomarkers of interest that is currently missing during neuro-oncological interventions.

近年来，通过成像技术（如 MRI、PET、CT 等）的进步，术前中枢神经系统 (CNS) 病变的临床定位使神经外科医生在切除肿瘤时能够计划和导航远离功能性大脑位置。然而，由于无法在术中维持病变和非病变位置的准确空间信息，脑肿瘤手术治疗中的神经导航仍然是一个重大挑战。为了应对这一挑战，我们组建了一支由工程师、物理学家、数据科学家和神经外科医生组成的团队，开发一种创新的全光学术中成像系统，该系统基于 (i) 用于快速多波长光谱采集的高光谱成像 (HSI)，以及 (ii) 用于图像重建和分子指纹识别的人工智能 (AI)。我们的术中 HSI 系统 (HyperProbe) 将 (1) 绘制、监测和量化感兴趣的生物分子； (2) 手持式且用户友好； （3）应用基于人工智能的方法重建光谱图像、分析空间光谱数据以及开发和量化新型生物标志物。我们将在体模中验证所开发的能力，在体内对照神经导航成像的金标准模式，并最终在脑肿瘤手术期间提供原理证明。 HyperProbe 旨在提供目前在神经肿瘤干预期间缺失的感兴趣生物标志物的功能和结构信息。