Advancing Clinical Science in Pediatric Gastroparesis
Advancing Clinical Science in Pediatric Gastroparesis
批准号:
10319415
负责人:
Bruno Pedro Chumpitazi
金额:
$38.06万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-09-25 至 2027-07-31
关键词:
AdolescenceAdolescentAdultAffectAnxietyCaringCategoriesChildChildhoodClinicalClinical ResearchClinical SciencesClinical TrialsDataDevelopmentDiabetes MellitusDietitianDiseaseDistressDuodenumDyspepsiaEating BehaviorEpidemiologyEpigastriumEquipment and supply inventoriesEtiologyFoodFunctional Gastrointestinal DisordersFunctional disorderFutureGastric EmptyingGastritisGastroparesisGeneral PopulationGoalsHospital CostsHospitalizationHypersensitivityIncidenceIntestinal permeabilityKnowledgeLinkMeasuresMechanicsMental DepressionMethodologyMethodsMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesNatural HistoryNausea and VomitingObstructionOperative Surgical ProceduresOutcomePainParentsPatientsPopulationPrevalencePsychologistQuality of lifeQuestionnairesRadionuclide ImagingRegistriesResearchRoleSample SizeSatiationSeveritiesSeverity of illnessSiteStomachSymptomsTestingToddlerTreatment outcomeValidationVisceralVomitingWaterWorkage groupage relatedanxiety stateschildren&aposs depression inventorycohortcommon symptomcomorbiditydietarydisabilityearly satietyeosinophilfield studyfunctional disabilitygastrointestinalimprovedinnovationinsightinterdisciplinary approachmast cellmortalityneuropathologynovelpain catastrophizingpediatric patientsprospectivepsychosocialrecruittooltrait
中文摘要
胃轻瘫(GP)在儿童和成人的特点是延迟胃排空在缺席
英文摘要
Gastroparesis (GP) in children and adults is characterized by delayed gastric emptying in the absence of
mechanical obstruction. GP is associated with significant morbidity and mortality yet little is known regarding its
incidence, prevalence, and natural history in children. This knowledge gap in pediatric GP is exacerbated by the
overlap in symptoms and pathophysiology with functional dyspepsia (FD), a common disorder in adults and
children. The limited data suggests significant differences between clinical symptoms and pathophysiology of
GP and FD in children vs adults. Thus, data regarding GP and FD in adults is unlikely to provide insight and fill
the knowledge gaps regarding GP and FD in children. These issues (among others) underscore need for
childhood GP- and FD-specific research strategies. Thus, the goals of this renewal application are to build on
and extend our previous Pediatric Registry work as part of the NIDDK Gastroparesis Consortium (GpCRC)
(e.g., recruitment into the Registry, development of a pediatric Quality of Life and Symptom GP Module;
PedsQL/Symptom GP Module), ultimately, to determine the factors contributing to disease severity measured
by quality of life and symptoms. Our Specific Aims are:
Aim 1 – Complete validation of the PedsQL/Symptom GP Module via field testing and develop an
analogous module for pediatric FD using qualitative measures followed by field testing.
Aim 2- Determine the role of the following potential contributors to disease severity in pediatric GP
and FD:
2a - Pathophysiologic: a) Visceral hypersensitivity (via water load satiety testing); b) Gastric
accommodation (via intragastric meal distribution); c) Gastric emptying rate (scintigraphy); d) Duodenal/gastric
inflammation (mast cells and eosinophils); e) Gastric/proximal gut barrier function (gut permeability).
2b - Psychosocial distress: Engage with psychologists to assess a) Somatization (Children’s Somatization
Inventory); b) Depression (Children’s Depression Inventory) c) Anxiety (State-Trait Anxiety Inventory); d)
Disability (Functional Disabilities Inventory); e) Catastrophizing (Pain Catastrophizing Scale).
2c - Dietary intolerances: Engage with dietitians, patients, and parents to determine self-identified food
intolerances and eating behaviors in children with GP and FD.
Aim 3 - To accomplish the above, expand Registry recruitment by including more pediatric centers, with some
linked to adult GpCRC sites in order to begin to explore barriers to transition from pediatric to adult care.
This innovative multidisciplinary approach will prospectively begin to fill the vast knowledge void regarding
GP and FD in children. The current proposal is responsive to RFA-DK-20-504 by achieving among other goals,
to: build on our previous gains, enlist expertise of psychologists and dietitians, expand recruitment sites, and
study pediatric to adult care transition.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Advancing Clinical Science in Pediatric Gastroparesis
-
批准号:10851126
-
项目类别:
-
资助金额:$31.8万
-
财政年份:2016
-
负责人:Bruno Pedro Chumpitazi
-
依托单位:
Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBS
-
批准号:8833276
-
项目类别:
-
资助金额:$17.18万
-
财政年份:2014
-
负责人:Bruno Pedro Chumpitazi
-
依托单位:
Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBS
-
批准号:9244023
-
项目类别:
-
资助金额:$18.15万
-
财政年份:2014
-
负责人:Bruno Pedro Chumpitazi
-
依托单位:
Intestinal Microbiome Fructan Metabolism and Symptom Generation in Childhood IBS
-
批准号:8679136
-
项目类别:
-
资助金额:$17.18万
-
财政年份:2014
-
负责人:Bruno Pedro Chumpitazi
-
依托单位:
海外基金