A Novel Ruthenium Antimicrobial Platform Technology - Preventing and Treating Multi-Drug Resistant Infections

MetalloBio是谢菲尔德大学的衍生公司，由Kirsty Smitten博士和Jim Thomas教授共同创立。MetalloBio正在开发一系列新的抗菌化合物。这些化合物正在开发中，作为治疗呼吸道细菌感染的药物和作为医疗器械涂层，以防止在医疗器械部位发生感染。支撑该平台的化合物比目前的抗生素更活跃，具有新的作用机制，几乎没有出现耐药性，代表了一种新的抗菌药物类别。从这个角度来看，一种新的抗菌药物已经有30多年没有进入临床了。抗菌药物正处于临床前开发阶段，涂层技术原型已经开发完成。该奖项加速了MetalloBio的技术发展，缩短了上市时间，通过提高患者的生活质量和降低死亡率来实现最大的影响。该项目将允许MetalloBio完成潜在客户所概述的关键临床前实验，包括与呼吸道感染相关的90种细菌菌株的广泛抗菌筛选。此外，这将使研究小组能够将抗菌剂的合成规模扩大到可以融入聚合物用于商业应用的水平。最后，将与一家排名前10的医疗器械公司一起研究商业有效性，以确定该聚合物是否可以用于覆盖其医疗器械技术。

MetalloBio is a University of Sheffield spin-out company co-founded by Dr Kirsty Smitten and Professor Jim Thomas. MetalloBio are developing a new series of antimicrobial compounds. The compounds are being developed as drugs to treat respiratory bacterial infections and as medical device coatings to prevent infections from developing at the medical device site.The compounds that underpin the platform are more active than current antibiotics, have a novel mechanism of action, little-to-no emergence of resistance and represent a new antimicrobial class. To put this into perspective a new antimicrobial class has not reached the clinic in over 30-years. The antimicrobial is in the preclinical stage of development and the coating technology prototype has been developed.This award accelerate MetalloBio's technology's development and reduce the time to the market, where maximum impact through improved patient quality of life and reduced death rates will be achieved. The project will allow MetalloBio to complete key preclinical experiments outlined by potential customers as essential, including a wide antimicrobial screen of 90 bacterial strains relevant to respiratory infections. Additionally, it will allow the team to scale the synthesis of the antimicrobials to a level that will allow incorporation into polymers for commercial applications. Finally, commercial validity will be studied with a top 10 medical device company, to determine if the polymer can be used to coat their medical device technology's.