Spring Mediated Enterogenesis

春季介导的肠发生

• 批准号: 10338557
• 负责人: James C Dunn
• 金额: $ 35.43万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10338557
• 关键词: Affect; Animal Model; Animals; Area; Back; Caliber; Cells; Clinical; Clinical Trials; Coiled Springs; Data; Devices; Dimensions; Disease; Eating; Excision; Failure; Family suidae; Goals; Growth; Health; Health Care Costs; Intestinal Obstruction; Intestinal Perforation; Intestines; Intravenous; Lead; Length; Liver Failure; Liver diseases; Malabsorption Syndromes; Measures; Mechanics; Mediating; Modeling; Operative Surgical Procedures; Parenteral Nutrition; Patient Care; Patients; Phase I Clinical Trials; Positioning Attribute; Rattus; Research; Research Proposals; Residual state; Rodent; Rodent Model; Safety; Short Bowel Syndrome; Small Intestines; Supportive care; Surface; Surgical sutures; Techniques; United States; Weaning; Work; curative treatments; distraction; improved; improved functioning; innovation; jejunum; mechanical device; nitinol; novel; nutrition; porcine model; preclinical study; scale up; treatment strategy

Project Summary Lengthening the small intestine is a potentially curative therapy for patients with intestinal failure due to short bowel syndrome. Short bowel syndrome is the end result of devastating diseases that affect the small intestine. Patients with short bowel syndrome have malabsorption and cannot eat normal meals. The current therapy for short bowel syndrome consists of providing parenteral nutrition, optimizing the health of the remnant intestine, and enhancing intestinal adaptation. While parenteral nutrition has dramatically improved their survival, many patients with short bowel syndrome cannot be weaned from parenteral nutrition and develop end stage liver disease. Over the last decade, we developed and refined devices to lengthen the small intestine. By applying a gradual force to a segment of the small intestine separated from continuity, we were able to triple the length of the small intestine in rats and pigs. There was a net growth of the intestinal cell mass and an increase in the absorptive surface area. The lengthened segment was functional when it was restored back into intestinal continuity. These studies demonstrated the potential of mechanical intestinal lengthening as a novel treatment of patients with short bowel syndrome. In this proposed research, we will obtain data on spring devices that will lengthen the intestine that are still in intestinal continuity in different size animals. We will also develop ways to maximize intestinal lengthening with multiple springs applied repeatedly. Lastly, we will employ the spring in a porcine short bowel model. If successful, these studies will lead to a Phase 1 clinical trial of these devices in patients with short bowel syndrome. This approach will revolutionize the treatment strategy of patients with short bowel syndrome.

项目总结