Understanding and measuring the impact of stigma on PrEP adherence among adolescent girls and young women in Kenya: identifying targets for future interventions

了解和衡量耻辱对肯尼亚少女和年轻女性坚持 PrEP 的影响:确定未来干预措施的目标

基本信息

  • 批准号:
    10330076
  • 负责人:
  • 金额:
    $ 14.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-01 至 2022-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Adolescent girls and young women (AGYW) in sub-Saharan Africa are highly vulnerable to HIV. In Kenya, youth ages 15–24 account for 33% of new infections annually, and incidence is twice as high in AGYW as it is in young men. Pre-exposure prophylaxis (PrEP) is a powerful tool to reduce HIV acquisition, but adherence has been low among AGYW, limiting its protective benefit. PrEP stigma—typically based on stereotypes of users as “promiscuous” or HIV-positive—is emerging as a key barrier to adherence. However, evidence among AGYW is limited. The goal of the proposed study is to improve our understanding of stigma- related barriers to PrEP adherence among AGYW in Kenya and identify potential intervention approaches and targets. The study will build on our recent research to adapt the Health Stigma and Discrimination Framework for PrEP stigma among AGYW and will leverage our successful partnership with Impact Research and Development Organization (IRDO), which is implementing the DREAMS Initiative in Siaya County, Kenya and has initiated more than 3,900 AGYW on PrEP. We will build stigma research capacity at IRDO by mentoring early-career Research Associates and training local AGYW youth researchers. The specific aims are to (1) develop and validate a scaled instrument to measure relevant dimensions of PrEP stigma among AGYW who use PrEP, and (2) assess the relationship between stigma and PrEP adherence and identify intervention targets. Aim 1 will use youth-led participatory research to refine the PrEP stigma framework with AGYW, identify key components of PrEP stigma, and understand how related types of stigma (HIV, gender, and sexuality) overlap with PrEP stigma. Findings will inform the development of the initial scale. After cognitive testing, the scale will be piloted with 200 AGYW to confirm the hypothesized factor structure and assess reliability and construct validity, including whether it is distinct from other types of stigma. Aim 2 will use a mixed methods approach. For Aim 2a, we will conduct a quantitative survey with 300 AGYW PrEP users to determine the prevalence of various types and dimensions of stigma impacting AGYW, measuring PrEP stigma with the Aim 1 scale. Participants will be prospectively followed using DREAMS program data to test the association of baseline stigma with PrEP adherence (both persistence and execution) over the next 6 months. For Aim 2b, we will conduct qualitative focus group discussions with AGYW and their key influencers (family members, peers, partners, and health care providers) to understand stigmatizing attitudes and behaviors and assess the acceptability of candidate interventions. The qualitative and quantitative findings will be integrated to identify future intervention targets and approaches. This study’s focus on PrEP stigma among Kenyan AGYW is innovative and fills a critical gap in efforts to end the HIV epidemic. The findings will lay the groundwork to develop and test a culturally tailored, age-appropriate stigma reduction intervention, which will aim to increase PrEP adherence in this vulnerable population.
项目总结/文摘

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Sarah Tyler Roberts其他文献

Sarah Tyler Roberts的其他文献

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{{ truncateString('Sarah Tyler Roberts', 18)}}的其他基金

Tu'Washindi: A relationship-focused intervention to reduce GBV and increase PrEP uptake and adherence among Kenyan AGYW
TuWashindi:以关系为中心的干预措施,旨在减少肯尼亚 AGYW 中的 GBV 并提高 PrEP 的采用和依从性
  • 批准号:
    10669083
  • 财政年份:
    2021
  • 资助金额:
    $ 14.93万
  • 项目类别:
Tu'Washindi: A relationship-focused intervention to reduce GBV and increase PrEP uptake and adherence among Kenyan AGYW
TuWashindi:以关系为中心的干预措施,旨在减少肯尼亚 AGYW 中的 GBV 并提高 PrEP 的采用和依从性
  • 批准号:
    10472019
  • 财政年份:
    2021
  • 资助金额:
    $ 14.93万
  • 项目类别:
Tu'Washindi: A relationship-focused intervention to reduce GBV and increase PrEP uptake and adherence among Kenyan AGYW
TuWashindi:以关系为中心的干预措施,旨在减少肯尼亚 AGYW 中的 GBV 并提高 PrEP 的采用和依从性
  • 批准号:
    10323074
  • 财政年份:
    2021
  • 资助金额:
    $ 14.93万
  • 项目类别:
Understanding and measuring the impact of stigma on PrEP adherence among adolescent girls and young women in Kenya: identifying targets for future interventions
了解和衡量耻辱对肯尼亚少女和年轻女性坚持 PrEP 的影响:确定未来干预措施的目标
  • 批准号:
    10220170
  • 财政年份:
    2020
  • 资助金额:
    $ 14.93万
  • 项目类别:
Understanding and measuring the impact of stigma on PrEP adherence among adolescent girls and young women in Kenya: identifying targets for future interventions
了解和衡量耻辱对肯尼亚少女和年轻女性坚持 PrEP 的影响:确定未来干预措施的目标
  • 批准号:
    10054077
  • 财政年份:
    2020
  • 资助金额:
    $ 14.93万
  • 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
  • 批准号:
    9403567
  • 财政年份:
    2017
  • 资助金额:
    $ 14.93万
  • 项目类别:
Gender-Based Violence and HIV Risk: Mediating Pathways and Prevention Strategies
基于性别的暴力和艾滋病毒风险:调解途径和预防策略
  • 批准号:
    9077088
  • 财政年份:
    2015
  • 资助金额:
    $ 14.93万
  • 项目类别:
Gender-Based Violence and HIV Risk: Mediating Pathways and Prevention Strategies
基于性别的暴力和艾滋病毒风险:调解途径和预防策略
  • 批准号:
    8918359
  • 财政年份:
    2015
  • 资助金额:
    $ 14.93万
  • 项目类别:

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