Efficient and rapidly SCAlable EU-wide evidence-driven Pandemic response plans through dynamic Epidemic data assimilation

流行病有可能扰乱我们的日常生活，影响社会的每一个部分。引起COVID-19疾病的SARS-CoV-2痛苦地表明，反应太晚，在一个支离破碎的方式和/或不同部门和国家之间的协调太少，导致了巨大的人力和经济成本。ESCAPE的主要目标是通过提供循证指南、标准化研究方案、回顾性见解和数字解决方案来提高早期大流行应对计划的效率和可扩展性，这些解决方案将支持科学家制作和整合证据，并告知公共卫生当局做出决策，以避免或减少疾病和社会负担。该项目将提供知识和工具，加强欧洲对病原体X大流行的准备。其中包括一个以科学为基础的蓝图，以更快和更好地管理流行病的决策，改善数据可用性，收集和共享的工具和框架，以及先进的分析和模型，以了解和预测候选响应情景下病原体X的传播动态。ESCAPE还将根据SARS-CoV-2大流行确定病原体X管理成败的决定因素，帮助制定未来大流行的有效应对策略。此外，该项目还将促进建立一个多利益攸关方的智慧社区，使决策者、科学界、媒体和公众能够更好地分享知识和开展合作，确保对未来的大流行病作出更有效的反应。从长远来看，通过改善大流行病的准备和对病原体X大流行病的反应的有效性，该项目将有助于减少大流行病期间的健康负担和潜在的负面社会和经济后果，并提高决策者和公众对基于科学的解决方案的信心。

Pandemics have the potential to disrupt our daily lives and to affect every part of society. SARS-CoV-2 causing COVID-19 disease painfully showed how responding too late, in a fragmented mannar and/or with too little coordination across different sectors and countries, led to huge human and economic costs. ESCAPE’s main objective is to improve efficiency and scalability of early pandemic response plans by providing evidence-based guidelines, standardised research protocols, retrospective insights, and digital solutions that will support scientists in producing and integrating evidence and inform public health authorities in taking decisions to avert or reduce disease and societal burden. The project will provide knowledge and tools that will enhance Europe’s preparedness for a pandemic of pathogen X. These include a science-based blueprint for faster and better decision-making in managing pandemics, tools and frameworks to improve data availability, collection and sharing, as well as advanced analytics and models to understand and project transmission dynamics of pathogen X under candidate response scenarios. ESCAPE will also identify determinants of success and failure in managing pathogen X based on the SARS-CoV-2 pandemic, helping to develop effective response strategies for future pandemics. In addition, the project will contribute to fostering a multi-stakeholder intelligent community allowing improved knowledge sharing and cooperation between policy-makers, the scientific community, the media and the public, ensuring a much more effective response to future pandemics. In the long-term, by improving pandemic preparedness and the effectiveness of response to a pandemic of pathogen X, the project will contribute to reducing health burden and potential negative societal and economic consequences during pandemics, as well as increase the confidence of policy makers and the public in science-based solutions.