Efficient and rapidly SCAlable EU-wide evidence-driven Pandemic response plans through dynamic Epidemic data assimilation

流行病有可能扰乱我们的日常生活，影响社会的方方面面。SARS-CoV-2引起的COVID-19疾病痛苦地表明，应对太晚，以分散的方式和/或不同部门和国家之间的协调太少，导致巨大的人力和经济成本。ESCAPE的主要目标是通过提供循证指南、标准化研究方案、回顾性见解和数字解决方案，提高大流行早期应对计划的效率和可扩展性，这些解决方案将支持科学家产生和整合证据，并为公共卫生当局做出决策提供信息，以避免或减少疾病和社会负担。该项目将提供知识和工具，加强欧洲对X病原体大流行的防范，其中包括在管理大流行病方面更快更好地做出决策的科学蓝图，改善数据可用性、收集和共享的工具和框架，以及在候选应对方案下了解和预测X病原体传播动态的高级分析和模型。ESCAPE还将确定基于SARS-CoV-2大流行管理病原体X的成败决定因素，帮助制定针对未来大流行的有效应对战略。此外，该项目将有助于建立一个多利益攸关方的智能社区，从而改善决策者、科学界、媒体和公众之间的知识共享和合作，确保对未来的大流行病作出更有效的反应。从长远来看，通过改进大流行病的防范和对X病原体大流行病的有效应对，该项目将有助于减轻大流行病期间的健康负担和潜在的负面社会和经济后果，并增强决策者和公众对基于科学的解决办法的信心。

Pandemics have the potential to disrupt our daily lives and to affect every part of society. SARS-CoV-2 causing COVID-19 disease painfully showed how responding too late, in a fragmented mannar and/or with too little coordination across different sectors and countries, led to huge human and economic costs. ESCAPE’s main objective is to improve efficiency and scalability of early pandemic response plans by providing evidence-based guidelines, standardised research protocols, retrospective insights, and digital solutions that will support scientists in producing and integrating evidence and inform public health authorities in taking decisions to avert or reduce disease and societal burden. The project will provide knowledge and tools that will enhance Europe’s preparedness for a pandemic of pathogen X. These include a science-based blueprint for faster and better decision-making in managing pandemics, tools and frameworks to improve data availability, collection and sharing, as well as advanced analytics and models to understand and project transmission dynamics of pathogen X under candidate response scenarios. ESCAPE will also identify determinants of success and failure in managing pathogen X based on the SARS-CoV-2 pandemic, helping to develop effective response strategies for future pandemics. In addition, the project will contribute to fostering a multi-stakeholder intelligent community allowing improved knowledge sharing and cooperation between policy-makers, the scientific community, the media and the public, ensuring a much more effective response to future pandemics. In the long-term, by improving pandemic preparedness and the effectiveness of response to a pandemic of pathogen X, the project will contribute to reducing health burden and potential negative societal and economic consequences during pandemics, as well as increase the confidence of policy makers and the public in science-based solutions.