Biomic_AUTh, Center of Excellence in Metabolomics research (BiACEM)

Biomic_AUTh，代谢组学研究卓越中心 (BiACEM)

• 批准号: 10050966
• 金额: $ 17.99万
• 依托单位: IMPERIAL COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10050966
• 关键词: Biomic_AUTh; Center; Excellence; Metabolomics; research

BiACEM aims to link Biomic_AUT an interdisciplinary laboratory of the Aristotle University Thessaloniki, with three world leading metabolomics research groups: the bioinformatics team of Imperial College London, the metabolomics/lipidomic research team Fundación Universitario San Pablo CEU (Madrid) and HMGU. Via the realization of the project, strategic partnership and networking will be developed, promoting the research status and capacity of Biomic researchers and covering existing gaps in know-how and technology. Long term aim of Biomic is to lead, develop new concepts, analytical methods, and ways to produce or analyze comprehensive datasets, furthering the application of metabolomics in life science and biomarker discovery. To reach this level, existing pinch points should be addressed. Themes identified as strengths of the advanced partners and key areas of Biomic improvement include: development and organisation of lipidomic experimentation in LC-MS, exploitation of advanced mass spectrometry acquisition and ion mobility spectrometry data, metabolite identification, effective mining and use of multiple data sets, data management, artificial intelligence tools for metabolomics data and for text mining (natural language processing), data fusion, effective biochemical interpretation. Transfer of knowledge is organised as a series of training events, webinars, e-meetings, staff exchanges and collaborative research with the advanced partners. Emphasis is also put on training on research management and setting a research management unit in Biomic. Three clinical biomarker discovery demonstration projects constitute the research element of BiACEM. Realization of the project will have major impact on Biomic, their collaborators and the Greek metabolomics ecosystem as it will remedy weaknesses, and provide new, timely and necessary technological solutions for the first time to Greek scientists, promoting level or research and innovation.

BiACEM旨在将Bioic_AUT（塞萨洛尼基亚里士多德大学的跨学科实验室）与三个世界领先的代谢组学研究小组联系起来：伦敦帝国理工学院的生物信息学团队，代谢组学/脂质组学研究团队Fundación Universitario San巴勃罗CEU（马德里）和HMGU。通过该项目的实施，将发展战略伙伴关系和网络，提高生物组学研究人员的研究地位和能力，并弥补知识和技术方面的现有差距。生物组学的长期目标是引领、开发新概念、分析方法和方法来产生或分析综合数据集，促进代谢组学在生命科学和生物标志物发现中的应用。为了达到这一水平，应解决现有的夹点。被确定为高级合作伙伴优势的主题和生物组学改进的关键领域包括：开发和组织LC-MS中的脂质组学实验，利用先进的质谱采集和离子迁移谱数据，代谢物鉴定，有效挖掘和使用多个数据集，数据管理，用于代谢组学数据和文本挖掘的人工智能工具（自然语言处理），数据融合，有效的生化解释。知识转移通过一系列培训活动、网络研讨会、电子会议、员工交流以及与高级合作伙伴的合作研究来组织。还强调研究管理方面的培训，并在生物技术领域设立一个研究管理单位。三个临床生物标志物发现示范项目构成了BiACEM的研究元素。该项目的实现将对Biomic、其合作者和希腊代谢组学生态系统产生重大影响，因为它将弥补弱点，并首次为希腊科学家提供新的、及时和必要的技术解决方案，促进研究和创新水平。