Biochemistry, Cellular and Molecular Biology Program

项目概要/摘要 生物化学，细胞和分子生物学（BCMB）研究生课程已经培养了700多名 科学家自1972年以来BCMB作为七个基础科学部门的主要培训计划， 约翰霍普金斯大学医学院，是美国历史最悠久的多学科研究生课程之一。 国家有100名教师积极参与研究，教学和导师。的 参加该计划的部门是生物化学，生物物理和生物物理化学， 细胞生物学、分子生物学和遗传学、神经科学、药理学和分子科学，以及 physiology.平均每年有22名学生入学并获得博士学位。平均5.7年。 BCMB计划的目标是：（1）提供广泛而深入的科学课程;（2）提供 在严格的，可重复的和负责任的实验研究中进行纵向培训;（3）提供以下方面的培训： （4）为学员提供探索职业选择的活动;以及（5）招聘和支持 在一个包容的环境中的多样化的学生群体。这些目标将通过严格的 课程涵盖第一年的研究，包括课程集中在大分子（能量学， 结构和功能），分子生物学和基因组学，遗传学，生物学中的有机机制，细胞结构 动力学，途径和调节。有一个新的强烈强调生物信息学和 计算能力贯穿整个课程。有多个论文讨论课程， 第1年至第3年，以支持严格和可重复研究的培训。有一些讨论课程， 专注于负责任的研究行为，除了部门为基础的研讨会，学生在推进 他们的论文工作。口头和书面陈述技能通过讲习班在整个培训过程中得到发展 针对不同的具体任务（口试、粉笔讲座、手稿和提案写作）。专业 发展和职业规划是该计划的一个组成部分，通过研讨会和课程进行 在整个培训期间，以及各种实习机会。大多数学生发表多项研究 论文和培训结束时，介绍了一个公开研讨会和提交博士论文。 BCMB毕业生在学术界，政府和工业界的各级领导职位。的成功 我们的学生是由教师和学员之间的合作和互动的非凡水平培养。 特别强调将基础科学中的概念突破应用于与下列问题有关的问题： 人类健康和疾病。在这里，我们要求25个培训补助金插槽任命培训补助金合格的学生 在项目的头两年。

PROJECT SUMMARY/ABSTRACT The Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program has trained more than 700 scientists since 1972. BCMB serves as the major training program for seven basic science departments at the Johns Hopkins University School of Medicine and is one of the oldest multidisciplinary graduate programs in the country. There are 100 faculty members actively involved in research, teaching and as mentors. The Departments that participate in the program are Biological Chemistry, Biophysics and Biophysical Chemistry, Cell Biology, Molecular Biology and Genetics, Neuroscience, Pharmacology and Molecular Sciences, and Physiology. An average of 22 students matriculate each year and obtain their Ph.D. in an average of 5.7 years. The objectives of the BCMB program are: (1) to provide a broad and deep science curriculum; (2) to provide longitudinal training in rigorous, reproducible and responsible experimental research; (3) to provide training in professional skills; (4) to provide activities for trainees to explore career options; and (5) to recruit and support a diverse student population in an inclusive environment. These objectives will be met through a rigorous curriculum covering the first year of study that includes courses focused on macromolecules (energetics, structure and function), molecular biology and genomics, genetics, organic mechanisms in biology, cell structure and dynamics, and pathways and regulation. There is a new strong emphasis on bioinformatics and computational skills throughout the coursework. There are multiple paper discussion courses extending from years 1 through 3 to support training in rigorous and reproducible research. There are discussion courses that focus on responsible conduct of research, in addition to department-based workshops as students advance in their thesis work. Oral and written presentation skills are developed throughout training through workshops targeting different specific tasks (oral exams, chalk talks, manuscript and proposal writing). Professional development and career planning is an integral part of the program, occurring through workshops and courses throughout the training period, as well as diverse internship offerings. Most students publish multiple research papers and the training concludes with presentation of a public seminar and submission of the doctoral thesis. BCMB graduates hold leadership positions at all levels of academia, government and industry. The success of our students is fostered by an extraordinary level of collaboration and interaction among the faculty and trainees. Special emphasis is placed on applying conceptual breakthroughs in basic science to problems relevant to human health and disease. Here we request 25 training grant slots to appoint training grant eligible students during their first two years in the program.