Biochemistry, Cellular and Molecular Biology Program

项目摘要/摘要 生物化学、细胞和分子生物学(BCMB)研究生项目已经培训了700多人 自1972年以来一直是科学家。BCMB是该校七个基础科学系的主要培训项目 约翰霍普金斯大学医学院，是历史最悠久的多学科研究生课程之一 国家。有100名教职员工积极参与研究、教学和担任导师。这个 参加该计划的系有生物化学、生物物理和生物物理化学， 细胞生物学、分子生物学和遗传学、神经科学、药理学和分子科学 生理学。平均每年有22名学生入学，平均在5.7年内获得博士学位。 BCMB计划的目标是：(1)提供广泛而深入的科学课程；(2)提供 严格、可重复和负责任的实验研究方面的纵向培训；(3)提供 专业技能；(4)为学员提供探索职业选择的活动；及(5)招聘和支援 在一个包容的环境中，学生群体多样化。这些目标将通过严格的 涵盖第一年学习的课程，包括专注于大分子的课程(能量学， 结构和功能)、分子生物学和基因组学、遗传学、生物学中的有机机制、细胞结构 和动力，以及路径和规则。生物信息学和生物信息学受到了新的重视 在整个课程中掌握计算技能。有多个论文讨论课程，从 从第1年到第3年，支持严谨和可重复的研究培训。有一些讨论课程， 专注于负责任的研究，除了在学生进步的过程中以系为基础的研讨会 他们的论文很有成效。口头和书面演示技能在通过研讨会的培训中得到发展 针对不同的具体任务(口试、粉笔演讲、手稿和提案写作)。专业人士 发展和职业规划是该方案的一个组成部分，通过讲习班和课程进行。 在整个培训期间，以及各种实习机会。大多数学生发表多项研究 论文和培训的最后是一个公开研讨会和提交博士论文。 BCMB毕业生在学术界、政府和行业的所有级别都担任领导职务。的成功之处 我们的学生是由教师和实习生之间非凡的合作和互动培养出来的。 特别强调将基础科学中的概念突破应用于与 人类的健康和疾病。在此，我们申请25个培训资助名额，以任命符合培训资助条件的学生 在他们参加这个项目的头两年。

PROJECT SUMMARY/ABSTRACT The Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program has trained more than 700 scientists since 1972. BCMB serves as the major training program for seven basic science departments at the Johns Hopkins University School of Medicine and is one of the oldest multidisciplinary graduate programs in the country. There are 100 faculty members actively involved in research, teaching and as mentors. The Departments that participate in the program are Biological Chemistry, Biophysics and Biophysical Chemistry, Cell Biology, Molecular Biology and Genetics, Neuroscience, Pharmacology and Molecular Sciences, and Physiology. An average of 22 students matriculate each year and obtain their Ph.D. in an average of 5.7 years. The objectives of the BCMB program are: (1) to provide a broad and deep science curriculum; (2) to provide longitudinal training in rigorous, reproducible and responsible experimental research; (3) to provide training in professional skills; (4) to provide activities for trainees to explore career options; and (5) to recruit and support a diverse student population in an inclusive environment. These objectives will be met through a rigorous curriculum covering the first year of study that includes courses focused on macromolecules (energetics, structure and function), molecular biology and genomics, genetics, organic mechanisms in biology, cell structure and dynamics, and pathways and regulation. There is a new strong emphasis on bioinformatics and computational skills throughout the coursework. There are multiple paper discussion courses extending from years 1 through 3 to support training in rigorous and reproducible research. There are discussion courses that focus on responsible conduct of research, in addition to department-based workshops as students advance in their thesis work. Oral and written presentation skills are developed throughout training through workshops targeting different specific tasks (oral exams, chalk talks, manuscript and proposal writing). Professional development and career planning is an integral part of the program, occurring through workshops and courses throughout the training period, as well as diverse internship offerings. Most students publish multiple research papers and the training concludes with presentation of a public seminar and submission of the doctoral thesis. BCMB graduates hold leadership positions at all levels of academia, government and industry. The success of our students is fostered by an extraordinary level of collaboration and interaction among the faculty and trainees. Special emphasis is placed on applying conceptual breakthroughs in basic science to problems relevant to human health and disease. Here we request 25 training grant slots to appoint training grant eligible students during their first two years in the program.