Core E: Data Management

项目摘要/摘要：核心E(数据管理核心) 数据管理核心(核心E)的目标是支持征聘数据活动，提供高能力 ReadD-ADSP核心和项目的数据存储和运行大型计算任务。核心将：1) 支持和跟踪人口统计数据、认知测试结果、相关病史和认知史 来自确定和扩展核心(核心B)的问题，2)管理表型和基因组数据 由裁决和表型协调(核心C)和基因组学和生物标记(核心D)产生 核心，3)支持表型、基因和生物标记数据、分析结果的数据库(所有项目)，以及 注解(岩心C、D和项目)，4)对用于项目分析的基因分型数据进行归类，5) 为项目提供云计算分析支持和优化，6)为 ReadD-ADSP网站和仪表板。最终ReadD-ADSP资源，包括在此范围内收集的数据 应用和未来的生物标记物和全基因组测序，将为 阿尔茨海默病基因组学研究社区。群体特异性基因组关联的鉴定 这一资源的促进将既增加我们对阿尔茨海默氏症的生物学理解，又确保 这一治疗发展将使所有人口受益。

PROJECT SUMMARY/ABSTRACT: Core E (Data Management Core) The goal of the Data Management Core (Core E) is to support recruitment data activities, provide high-capacity data storage and run large computational tasks for the READD-ADSP cores and projects. The core will: 1) support and track demographics, cognitive testing results, pertinent medical history and history of cognitive problems from the Ascertainment and Outreach Core (Core B), 2) manage phenotype and genomic data produced by the Adjudication and Phenotype Harmonization (Core C) and Genomics and Biomarker (Cores D) Cores, 3) support databases for phenotypes, genotype and biomarker data, analysis results (all Projects), and annotations (Cores C, D and Projects), 4) perform imputation of genotyping data for analysis in Projects, 5) provide cloud computing analysis support and optimization to Projects, and 6) provide server support for the READD-ADSP website and dashboard. The final READD-ADSP resource, including data collected within this application and future biomarker and whole genome sequencing, will create an invaluable resource for the Alzheimer disease genomics research community. Identification of population specific genomic associations facilitated by this resource will both increase our biological understanding of Alzheimer's disease and ensure that therapeutic development will benefit all populations.