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中文摘要
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项目摘要 该计划的行政核心被整合到威尔斯的基因和细胞治疗计划中 印第安纳州大学儿科研究中心。它提供了授予前和授予后的机制, 该计划的管理,为定期和有效的互动的研究人员谁构成的关键 项目和核心的人员,并召集内部和外部咨询委员会, 正在进行的同行审查和对所有方案倡议的投入。行政核心在各级与 印第安纳州大学医学院和威尔斯儿科研究中心的中央管理机构。 行政核心将通过提供统计数据, 支持、组织数据收集和获取、交流和协调科学进步, 将受训者和学员纳入网络会议、会议和专题讨论会。核心将提供预算 监督该计划,并协调和维护机构监管批准的文件, 安排解决潜在的冲突,促进行政和科学电子文件共享 目的和出版物的准备,以及试剂,方案和实验模型的共享 以及科学界的其他人。此外,核心将促进 通过参与科学活动,帮助他们丰富培训经验, 讨论会、系列研讨会和年度专题讨论会。
英文摘要
PROJECT SUMMARY ABSTRACT The administrative core of this program is integrated into the Gene and Cell Therapy Program within the Wells Center for Pediatric Research at Indiana University. It provides the mechanism for pre- and post-award administration of the program, for regular and effective interactions of the investigators who constitute the key personnel of the projects and cores, and for assembling the Internal and External Advisory Committee to provide ongoing peer review and input to all programmatic initiatives. The administrative core interacts at all levels with the central administration of Indiana University School of Medicine and the Wells Center for Pediatric Research. The Administrative core will foster reproducibility and rigor in scientific progress through provision of statistical support, organization of data collection and access, exchange and coordination of scientific progress, and inclusion of trainees and mentees in web conferences, meetings, and symposia. The Core will provide budgetary oversight over the program and also coordinate and maintain documentation of institutional regulatory approvals, arrange for the resolution of potential conflicts, facilitate electronic file sharing for administrative and scientific purposes and for preparation of publications, as well as sharing of reagents, protocols, and experimental models within the program and with others in the scientific community. Further the Core will facilitate integration of trainees and mentees and help enrich their training experience through inclusion in scientific activities and discussions, a seminar series, and an annual symposium.
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Mechanisms of Innate and Adaptive Immune Responses to AAV-FVIII Gene Transfer
Toward Safer Gene Therapy for Hemophilia A
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