Cancer Informatics Shared Resource

癌症信息学共享资源摘要 共济会新重组的共享资源--癌症信息学共享资源 癌症中心(MCC)，为MCC成员提供最先进的生物信息学和临床信息学 服务，提供尖端方法、工具、基础设施以及专家咨询和协作，以 癌症研究人员。在前一时期，临床和翻译科学研究所(CTSI)和 卫生信息学研究所(IHI)在与MCC协商后，聘请康斯坦丁·阿维利斯博士担任 UMN的临床研究信息学官员。在Avenis博士的领导下，UMN的卫生信息学 迅速扩张，导致了组织结构重组和教师招聘。Avenis博士分享了 愿景与MCC领导整合生物信息学和医学信息学。因此，由以下人员创建了《信息社会责任公约》 整合MCC的生物信息学咨询服务和癌症临床信息学服务，以前 称为肿瘤学医学信息学服务(OMIS)，与健康信息学研究所合作 生物信息学咨询服务，同时在IHI维持一个以癌症为重点的信息学小组。这 战略集成将通过以下方式极大地扩展癌症信息学分析大规模数据集的能力 利用扩大的信息学资源，UMN包括几种影响较大的信息学方法 开发实验室，全方位的教育活动(包括学位课程和专业课程)， 高通量分析的信息学支持、安全的数据环境和临床试验管理 系统。国际癌症研究中心将在过去信息学成功的基础上，扩大和加强癌症生物信息学 研究开发，扩大咨询服务范围，指导临床基因组学发展 信息学，并开发系统范围的流程，以集成临床和基因组数据，以支持翻译 以及个性化肿瘤学的临床研究。 2016年，王金华教授，博士，著名的计算生物学家，对高密度的研究感兴趣。 通过癌症基因组学项目，被招募到Direct CISR。同样新的是他的直接下属，助理 领导癌症信息学咨询服务的艾哈迈德·阿布萨拉赫教授说。两把钥匙 生物信息学工作人员亚伦·萨弗博士和努里·阿尔佩·特米兹博士在CSR成立时被提升为IHI教职员工， 并与王博士密切合作，加强生物信息学合作和咨询。 在五年内，国际临床研究中心提供对临床研究任务至关重要的咨询服务和专业知识 主要领域：1)癌症基因组学和临床数据科学和分析；2)临床和基因组学数据共享， 基础设施集成和方法开发；3)开发分析新基因组学的方法 技术；4)大数据分析和精确肿瘤学方面的教育和培训；5)临床试验数据 管理基础设施和授权数据集成。除了支持管理需求外， MCC、CISR支持转化性治疗实验室(MSC- LIMS)和临床试验办公室(OnCore)。

Cancer Informatics Shared Resource Summary The Cancer Informatics Shared Resource (CISR), a newly reorganized Shared Resource of the Masonic Cancer Center (MCC), provides MCC members with state-of-the-art bioinformatics and clinical informatics services, providing cutting-edge methods, tools, infrastructure, and expert consultations and collaborations to cancer researchers. During the previous period, the Clinical and Translational Science Institute (CTSI) and Institute for Health Informatics (IHI), in consultation with the MCC, recruited Dr. Constantin Aliferis to be the Clinical Research Informatics Officer for the UMN. Under Dr. Aliferis' leadership, health informatics at the UMN has expanded rapidly, leading to organizational restructuring and faculty recruitments. Dr. Aliferis shared the vision witn MCC leadership of integrating Bioinformatics with Medical Informatics. Thus, CISR was created by integrating the MCC's BioInformatics consultation service and the cancer clinical informatics services, formerly known as Oncology Medical Informatics Services (OMIS), with the Institute for Health Informatics the Bioinformatics Consultation Services, while maintaining a cancer-focused informatics subgroup in IHI. This strategic integration will greatly expand the cancer informatics capacity for analyzing large-scale datasets by leveraging the expanded informatics resources the UMN including several high-impact informatics methods development labs, a full range of educational activities (including degree programs and specialized courses), informatics support of high-throughput assays, a secure data environment, and a clinical trial management system. CISR will build upon the past informatics successes to expand and strengthen cancer bioinformatics research development, increase the reach of its consulting service, guide the development of clinical genome informatics, and develop system-wide processes to integrate clinical and genomic data to support translational and clinical research for personalized oncology. In 2016, Professor Jinhua Wang, PhD, a noted computational biologist with a research interest in high- throughput cancer genomics projects, was recruited to Direct CISR. Also new is his direct report, Assistant Professor Ahmad AbuSalah, PhD, who leads the cancer informatics consultation services. Two key Bioinformatics staff, Drs. Aaron Sarver and Nuri Alpay Temiz, were promoted to IHI faculty when CISR formed, and are working closely with Dr. Wang to enhance bioinformatics collaborations and consulting. CISR provides consultation services and expertise critical to the clinical research mission of the MCC in five major areas: 1) cancer genomics and clinical data science and analytics; 2) clinical and genomics data sharing, infrastructure integration, and method development; 3) development of methods for analyzing new genomics technology; 4) education and training on big-data analytics and precision oncology; and 5) clinical trial data management infrastructure and grant data integration. In addition to supporting the administrative needs of the MCC, CISR supports significant database applications used by the Translational Therapy Laboratory (MSC- LIMS) and the Clinical Trials Office (OnCore).