Visual Function & Morphology Core

核心001（039）：视觉功能和形态核心（VFM核心），Gatesman-Ammer，核心负责人 项目概要/摘要 视觉功能和形态核心（VFM核心）已经从战略机构投资中脱颖而出 在超分辨率显微镜和功能视觉评估设备，以及杠杆支持， IDEA资助的计划（CoBRE、CTR、INBRE）提供了新技术、服务合同和 工资支持。VFM核心将用于所有四个拟议的研究项目，以及其他成员 VS-CoBRE，它将作为实验设计，数据采集和功能的焦点 分析. VFM核心还将根据需要提供设备监督、培训和援助， 为视觉科学卓越中心的项目领导者创造一个有利于成功的环境。 除了设备和专业知识，VFM核心将提供传输电子技术援助， 显微镜制备、组织学样本制备、ERG/OKR评估和电穿孔/眼眶 注射剂在机构支助下建立的现有能力也将纳入 VFM核心。其中包括四个超分辨率显微镜系统，一个透射电子显微镜， 明场和荧光成像系统以及视觉功能评估设备。该提案描述了 设施沿着的服务及其管理计划、费用结构、优先顺序、质量保证 计划和战略，以维持设施的生命周期和超越项目。具体目标是：1） 推进基础和转化研究，并提供必要的工具和专业知识，以促进 视觉科学研究项目负责人的生产力，以及2）开发VFM核心， 研究人员的首要目标是了解眼部异常的复杂性， 视力下降和失明。VFM核心将是一个有价值的和必要的一部分， 开发VS-CoBRE所需的基础设施，并带来视觉科学的进步， 影响视力障碍者的生活。

Core 001 (039): Visual Function & Morphology Core (VFM Core), Gatesman-Ammer, Core Lead PROJECT SUMMARY/ABSTRACT The Visual Function & Morphology Core (VFM Core) has emerged from strategic institutional investments in super resolution microscopy and functional visual assessment equipment, as well as leveraged support from IDeA-funded programs (CoBRE, CTR, INBRE) that have provided new technologies, service contracts and salary support. The VFM Core will be used by all four proposed research projects, as well as other members of the VS-CoBRE, where it will serve as the focal point for experimental design, data acquisition and functional analysis. The VFM Core will also provide equipment oversight, training, and assistance as needed to promote an environment conducive to success for the project leaders of the Visual Sciences Center of Excellence. In addition to equipment and expertise, the VFM Core will offer technical assistance in transmission electron microscopy preparations, histology sample preparation, ERG/OKR assessments, and electroporation/orbital injections. Existing capabilities that have been built with institutional support will also be incorporated into the VFM Core. These include four super-resolution microscopy systems, a transmission electron microscope, brightfield and fluorescent imaging systems, and visual function assessment equipment. The proposal describes services provided by the facility along with its management plan, fee structure, prioritization, quality assurance plan, and strategies to sustain the facility over the life of the project and beyond. The Specific Aims are to: 1) advance the basic and translational research and provide the necessary tools and expertise to advance productivity of the Visual Sciences CoBRE Research Project Leaders, and 2) develop the VFM Core for investigators who share the overarching goal to understand the complexities of ocular anomalies that may lead to decreases in visual acuity and blindness. The VFM Core will be a valued and necessary part of the infrastructure needed to develop the VS-CoBRE and to bring advances in visual sciences that will positively impact the lives of people with visual impairments.