Brain Circuitry of Inhibitory Control: Effects of Modulation

项目总结/摘要 这个COBRE项目旨在描绘和调节年轻人的反应抑制网络， 抑制对照（IC）范围。抑制控制在多种临床疾病中受损，包括 药物滥用强迫症和多动症防御素反应抑制可能与某些 临床病症、不良治疗反应和症状状态复发。拟议的目标 研究是1）表征IC网络的神经回路（右额下回（IFG）， 前补充运动区（pSMA），丘脑底核（PSMA））在健康的年轻成人的范围内， 使用基于任务的抑制控制（BRIEF-A抑制子量表）的广泛使用的临床测量评分 (stop信号任务）功能神经成像，2）通过2.0 mA阳极HD-tDCS调制IC网络到 右IFG，以及3）测试IFG和相关IC网络的功能状态与以下相关的假设： SST性能。使用本提案中详细介绍的以企业为目标的方法将为以下方面奠定基础： 个性化治疗。在这种情况下，有多种障碍，其中抑制失败是常见的， 有初步证据表明，这些疾病可能在相关疾病中共享潜在的病理生理学， 神经回路最终，对这种神经回路的更好理解可能会导致新的和改进的更多 个体化的基于神经回路的治疗基于共同的表型表现，而不是我们的 相对非特异性的诊断分类。

Project Summary/Abstract This COBRE project aims to delineate and modulate the response inhibition network in young adults with a range of inhibitory control (IC). Inhibitory control is impaired in a va​ riety of clinical disorders, including substance abuse, OCD, and ADHD. Def​ icits in response inhibition are likely related to development of certain clinical disorders, poor treatment response, and relapse to a symptomatic state. T​ he goals of the proposed study are to 1) characterize the neurocircuitry of the IC network (right inferior frontal gyrus (IFG), pre-supplementary motor area (pSMA), subthalamic nucleus (STN)) in healthy young adults with a range of scores on a widely-used clinical measure of inhibitory control (BRIEF-A Inhibit subscale) using task-based (stop signal task) functional neuroimaging, 2) modulate the IC network through 2.0 mA anodal HD-tDCS to the right IFG, and 3) test the hypothesis that the functional state of the IFG and the related IC network is related to SST performance. Using a symptom-targeted approach as detailed in this proposal will lay the groundwork for personalization of treatment. In this case, there are a variety of disorders in which inhibitory failure is common, and there is tentative evidence that these disorders may share underlying pathophysiology in relevant neurocircuits. Ultimately, greater understanding of this neurocircuitry may lead to new and improved more individualized neurocircuit-based treatments based on common phenotypic presentations rather than on our relatively unspecific diagnostic categorizations.