Brain Circuitry of Inhibitory Control: Effects of Modulation

项目摘要/摘要 这项Cobre项目旨在描绘和调节患有AFP的年轻人的反应抑制网络 抑制控制范围(IC)。抑制控制在一系列临床疾病中受到损害，包括 药物滥用、强迫症和多动症。反应抑制的​缺陷可能与某些疾病的发生有关 临床紊乱，治疗反应差，并复发为症状状态。​建议的目标 研究的目的是：1)描述IC网络的神经回路(右下额回， 健康年轻人的前辅助运动区(PSMA)、丘脑底核(STN) 使用基于任务的方法对一种广泛使用的临床抑制控制措施(Brief-A抑制子量表)的评分 (停止信号任务)功能神经成像，2)通过2.0 mA阳极HD-tDCS调制IC网络到 右IFG，以及3)检验IFG和相关IC网络的功能状态与以下条件相关的假设 SST性能。使用本建议书中详细介绍的针对症状的方法将为 个性化治疗。在这种情况下，有多种疾病，其中抑制失败是常见的， 有初步证据表明，这些疾病可能具有共同的潜在病理生理学 神经回路。最终，对这种神经回路的更多了解可能会带来更多新的和改进的 基于常见表型表现的个性化神经回路治疗，而不是基于我们的 相对不明确的诊断分类。

Project Summary/Abstract This COBRE project aims to delineate and modulate the response inhibition network in young adults with a range of inhibitory control (IC). Inhibitory control is impaired in a va​ riety of clinical disorders, including substance abuse, OCD, and ADHD. Def​ icits in response inhibition are likely related to development of certain clinical disorders, poor treatment response, and relapse to a symptomatic state. T​ he goals of the proposed study are to 1) characterize the neurocircuitry of the IC network (right inferior frontal gyrus (IFG), pre-supplementary motor area (pSMA), subthalamic nucleus (STN)) in healthy young adults with a range of scores on a widely-used clinical measure of inhibitory control (BRIEF-A Inhibit subscale) using task-based (stop signal task) functional neuroimaging, 2) modulate the IC network through 2.0 mA anodal HD-tDCS to the right IFG, and 3) test the hypothesis that the functional state of the IFG and the related IC network is related to SST performance. Using a symptom-targeted approach as detailed in this proposal will lay the groundwork for personalization of treatment. In this case, there are a variety of disorders in which inhibitory failure is common, and there is tentative evidence that these disorders may share underlying pathophysiology in relevant neurocircuits. Ultimately, greater understanding of this neurocircuitry may lead to new and improved more individualized neurocircuit-based treatments based on common phenotypic presentations rather than on our relatively unspecific diagnostic categorizations.