Advanced Tissue Pathology and Imaging Core

高级组织病理学和成像核心

• 批准号: 10338175
• 负责人: Paul E Harris
• 金额: $ 23.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10338175
• 关键词: Adipose tissue; Animals; Antibodies; Biology; Brain; Businesses; Categories; Cell surface; Cellular biology; Collaborations; Color; Colorado; Communities; Complex; Complications of Diabetes Mellitus; Confocal Microscopy; Consultations; Consumption; Core Facility; Data; Data Analyses; Development; Diabetes Mellitus; Diagnosis; Effectiveness; Equipment; Experimental Designs; Fluorescence Microscopy; Funding; Grant; Histologic; Histology; Histopathology; Image; Image Analysis; Immunofluorescence Immunologic; Immunohistochemistry; In Situ; In Situ Hybridization; Individual; Infrastructure; Institution; International; Islets of Langerhans; Laboratories; Lead; Liver; Maintenance; Microscope; Microscopy; Mission; Modeling; Monitor; Muscle; Pathogenesis; Pathology; Phenotype; Preparation; Procedures; Process; Publications; Quality Control; RNA; RNA analysis; Reagent; Reproducibility; Research; Research Personnel; Resolution; Resources; Sampling; Scanning; Services; Stains; Techniques; Technology; Time; Tissue Sample; Tissues; Training; Transmission Electron Microscopy; Universities; Work; analytical tool; base; bone; cellular pathology; cost; cost effective; cost effectiveness; data acquisition; equipment acquisition; falls; in vivo; instrument; islet; laser capture microdissection; live cell imaging; member; microscopic imaging; new technology; novel; operation; pathology imaging; programs; response; two photon microscopy; two-photon

Summary The Advanced Tissue Pathology and Imaging (ATPI) Core provides a wide spectrum of histopathology and microscopy services to meet the growing needs of diabetes researchers at Columbia University and affiliated institutions. Originally organized as a histopathology laboratory, the Core has evolved to meet the growing demands of DRC members by adding advanced microscopy services. The services of this Core continue to include high quality basic histological and microscopy services, and have been expanded to accommodate the changing and growing needs of DRC users and to incorporate newly developed reagents and technologies. Following the departure of former Core Director Dr. Sussel to lead the Barbara Davis Center at the University of Colorado, the Core has been ably led by Dr. Paul Harris, an internationally known investigator in islet imaging and cell biology. During the past cycle, the ATPI Core has processed 21,312 tissue samples, cut 248,342 sections and performed 21,381 immunohistochemical stains, including 4,862 samples by immunofluorescence. These services were provided to 30 DRC members supported by 84 grants. The resultant data have contributed to 12 new grants, and 93 Core-supported publications (61 as primary, 32 as secondary Core) (Overall Tables D and F, respectively). The Core plans to continue to provide advanced histophenotyping capabilities to the thriving Columbia University diabetes research community. To this end, the Core integrates its operation with that of the other DRC Core facilities, to maintain an investigator- oriented approach to service and development, to implement and sustain effective business practices, and to assist the DRC in its overall mission to advance our understanding of diabetes and its complications and develop new treatments for these conditions.

总结 高级组织病理学和成像（ATPI）核心提供了广泛的组织病理学和 显微镜服务，以满足糖尿病研究人员在哥伦比亚大学和附属 机构职能体系最初组织为组织病理学实验室，核心已经发展，以满足日益增长的 通过增加先进的显微镜服务，满足DRC成员的需求。本核心的服务将继续 包括高质量的基本组织学和显微镜服务，并已扩大，以适应 不断变化和不断增长的需求，并纳入新开发的试剂和技术。 在前核心主任Sussel博士离开后，他领导了大学的Barbara Davis中心。 在科罗拉多，核心一直由保罗哈里斯博士，一个国际知名的研究人员在胰岛 成像和细胞生物学。在过去的周期中，ATPI Core处理了21，312个组织样本， 248，342张切片，进行了21，381次免疫组化染色，其中4，862份样品通过 免疫荧光向30名刚果民主共和国成员提供了这些服务，得到了84笔赠款的支助。的 由此产生的数据促成了12项新的赠款和93项核心支持的出版物（61项是主要的， 32作为次要核心）（分别汇总表D和F）。核心计划继续提供 为蓬勃发展的哥伦比亚大学糖尿病研究社区提供先进的组织表型分析能力。到 为此，核心将其运作与其他刚果民主共和国核心设施的运作相结合，以维持一名调查员- 以服务和发展为导向的方法，实施和维持有效的业务做法， 协助DRC完成其总体使命，以提高我们对糖尿病及其并发症的认识， 为这些疾病开发新的治疗方法。