Can Bulk Milk Revolutionise TB Testing?

散装牛奶能否彻底改变结核病检测？

• 批准号: 10054234
• 金额: $ 49.1万
• 依托单位: SYNERGY FARM HEALTH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10054234
• 关键词: Bulk; Milk; Revolutionise; TB; Testing

A Defra review of UK bovine tuberculosis (bTB) strategy acknowledged bTB as the most pressing animal health problem in the UK.The Enferplex Bovine TB Antibody Test is a multiplex ELISA test for the detection of bTB in serum and milk, developed as a collaboration between three companies: SureFarm Ltd, a subsidiary of Synergy Farm Health Ltd (England), MV Diagnostics Ltd (Scotland) and Enfer Scientific ULC, part of Enfer Group (Eire).The test shows high sensitivity and specificity for the detection of bTB in bulk milk. The use of bulk milk as a surveillance tool offers significant opportunities in the control of TB, reducing costs to both farm and taxpayer through easier surveillance and improved control.The test is in the process of evaluation for approval by the World Office of Animal Health, which if accepted would require the UK Government to place mandatory restrictions on any herd testing positive. Therefore, there is a window of opportunity to develop understanding of the value that the test would bring to bTB control in the UK, without risk to the dairy industry and individual farms.We plan a GB wide, longitudinal study on the outcomes of testing bulk milk with the Enferplex bTB Antibody Test. Specifically, the study will focus on:1\. Test results obtained from herds currently under restriction. While the sensitivity of the test has already been elucidated for the OIE submission, this was based on a single time point and repeating the test may enhance sensitivity.2\. How many herds currently designated Officially Tuberculosis Free (OTF) would be determined positive by the test.3\. Understanding the relationship between seropositivity and/or the number of positive antigens and herd bTB status.4\. Understanding the predictive value of changes in seropositivity and/or the number of positive antigen reactions for tracking progress, or otherwise, of herd bTB control measures. Falling levels of either parameter may suggest a herd moving towards disease freedom; vice versa, rising levels may indicate that current actions are failing to control disease where the herd is already under restriction.5\. Understanding whether the test could be used as a monitoring tool for low risk OTF herds.The project has the full support of the National Farmers Union (NFU) and the British Cattle Veterinary Association (BCVA).

Defra对英国牛结核病（bTB）战略的审查承认bTB是英国最紧迫的动物卫生问题。Enferplex牛结核病抗体测试是一种用于检测血清和牛奶中bTB的多重ELISA测试，由三家公司合作开发：SureFarm Ltd， Synergy Farm Health Ltd（英格兰）的子公司，MV Diagnostics Ltd（苏格兰）和Enfer Scientific ULC， Enfer Group （Eire）的一部分。该方法对散装牛奶中bTB的检测具有较高的灵敏度和特异性。使用散装牛奶作为监测工具为控制结核病提供了重大机会，通过更容易的监测和改进的控制，降低了农场和纳税人的成本。该测试正在接受世界动物卫生办公室的评估，如果获得批准，将要求英国政府对任何检测呈阳性的畜群施加强制性限制。因此，我们有机会进一步了解这项测试对英国结核病控制的价值，而不会给乳制品行业和个体农场带来风险。我们计划在全英国范围内进行一项纵向研究，研究用Enferplex bTB抗体测试测试散装牛奶的结果。具体来说，研究将集中在：1\。从目前受限制的畜群获得的检测结果。虽然测试的敏感性已经在提交世界动物卫生组织时得到阐明，但这是基于单一时间点的，重复测试可能会提高灵敏度。有多少目前被指定为官方无结核病（OTF）的畜群将通过测试确定为阳性？了解血清阳性和/或阳性抗原数量与群体bTB状况之间的关系。了解血清阳性变化和/或抗原阳性反应数量的预测价值，以跟踪畜群bTB控制措施的进展或其他方面。任何一个参数水平的下降都可能表明畜群正朝着无疾病的方向发展；反之亦然，上升的水平可能表明，在畜群已经受到限制的地方，目前的行动未能控制疾病。了解该测试是否可作为低风险OTF牛群的监测工具。该项目得到了全国农民联盟（NFU）和英国牛兽医协会（BCVA）的全力支持。