Brain guard - a novel medical safety device
脑卫士——新型医疗安全装置
基本信息
- 批准号:10054526
- 负责人:
- 金额:$ 6.37万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Grant for R&D
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project is industrial research to gain critical knowledge for a new low-cost medical device which will be called the Brain-Buddy. It has a novel sensor technology that automatically alerts if flow in drainage lines (EVD) from the brain is interrupted. EVDs provide lifesaving stabilization in patients with acute brain injury after a trauma or brain bleed or when the brain pressure rises for other causes (infection, hydrocephalus). Each year 69 million individuals worldwide suffer a brain trauma. Annualy, 1.6 million cases requiring neurosurgery occur in high-income countries, 4.5 million occur in lower-middle-income countries. In addition to trauma, EVDs also provide benefits in the treatment of acute hydrocephalus. There are approximately 30,000 cases of hydrocephalus requiring neurosurgery in HICs and 740,000 cases in LMICs per year.Nvention believe the Brain-Buddy will highly benefit patients as, despite appropriate maintenance and surveillance of an EVD, complications such as obstruction and infection may arise in up to 54%.It is important to detect a blockage early as, in the early stage, gentle aspiration with a syringe or flushing (with saline or blood thinners) is more likely to clear the blockage. Also, sustained brain pressure above 40mmHg is associated with poor outcome, brain pressure above 30 mmHg is an independent predictor of higher short-term mortality. Research studies showed that brief periods of as little as 37minutes of pressure above 20mmHg are associated with lower outcomes at 6 months in adults with traumatic brain injury. These potentially devastating consequences reinforce the need for continuous monitoring. There is currently no device on the market to alarm in case of a blockage. With the Brain-Buddy, nurses will be alerted if flow stops and do not need to spend their valuable time continuously watching the system.This grant will support the critical investigation of the devices' potential and limitations. We will evaluate the prototype in the laboratory to see if it meets user requirements. The market will be assessed regarding strategic value/ease of access. The grant will allow strategically position of Nvention and refining our company growth and expansion strategy.The project is innovative as:* there is no such device on the market,* it lowers risk to patients by automatically alerting the clinician of a problem, rather than relying on staff noticing that fluid flow has stopped,* the Brain-Buddy is exceptionally low cost, making it widely affordable.Proof of concept experiments were successful.
该项目是一项工业研究,旨在获得一种新的低成本医疗设备的关键知识,该设备将被称为Brain-Buddy。它具有一种新颖的传感器技术,如果来自大脑的引流管(EVD)中的流量中断,则会自动发出警报。EVD为创伤或脑出血后的急性脑损伤患者或因其他原因(感染、脑积水)导致脑压升高的患者提供救生稳定。全世界每年有6900万人遭受脑外伤。每年,高收入国家有160万例需要神经外科手术的病例,中低收入国家有450万例。除创伤外,EVD还在急性脑积水的治疗中提供益处。每年约有30,000例脑积水需要在HIC和740,000例LMIC中进行神经外科手术。Nvention认为,Brain-Buddy将使患者受益匪浅,因为尽管对EVD进行了适当的维护和监测,但可能会出现高达54%的并发症,如阻塞和感染。用注射器轻轻抽吸或冲洗(用生理盐水或血液稀释剂)更有可能清除堵塞。此外,持续脑压高于40 mmHg与预后不良相关,脑压高于30 mmHg是短期死亡率较高的独立预测因素。研究表明,在创伤性脑损伤的成年人中,短至37分钟的20 mmHg以上的压力与6个月的较低结果相关。这些潜在的破坏性后果加强了持续监测的必要性。目前市场上没有在堵塞情况下报警的设备。有了Brain-Buddy,如果血流停止,护士将得到警报,而不需要花费宝贵的时间持续观察系统。这笔赠款将支持对设备潜力和局限性的关键调查。我们将在实验室对样机进行评估,看看它是否符合用户的要求。市场将根据战略价值/容易进入程度进行评估。该项目的创新之处在于:* 市场上没有这样的设备;* 它通过自动提醒临床医生问题来降低患者的风险,而不是依赖于工作人员注意到液体流动已经停止;* Brain-Buddy的成本非常低,使其能够广泛地负担得起。概念实验的证明是成功的。
项目成果
期刊论文数量(0)
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
- DOI:
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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