Risk Stratification Tool for Colorectal Polyp Surveillance

结直肠息肉监测的风险分层工具

• 批准号: 10054829
• 金额: $ 277.34万
• 依托单位: UNIVERSITY OF GLASGOW
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10054829
• 关键词: Risk; Stratification; Tool; Colorectal; Polyp

Bowel cancer screening is used to find bowel cancer and pre-cancerous lesions called polyps in patients without symptoms. The aim of screening is both to catch bowel cancers early -- making them easier to treat successfully -- and to prevent cancers by removing pre-cancerous polyps. Although timings vary across the UK, adults at a certain age are invited to submit a postal stool sample, and if traces of blood are detected, they are invited to a detailed test called colonoscopy.At colonoscopy, around 1 in 20 people are found to have cancer, while 1 in 3 have a polyp. Around a half of patients will go on to develop future polyps despite their removal at initial colonoscopy and therefore patients are asked to return for another colonoscopy in the future to look for new polyps. Guidelines exist for clinicians to help decide who needs a further colonoscopy and when they need it. However, these guidelines are not very accurate in predicting who is likely to form new polyps in the future, and a lot of people undergo colonoscopy who do not have a further polyp.Colonoscopies require patients to take powerful laxatives beforehand and sedatives during the procedure. There is a small risk of serious complication. Furthermore, patients need to attend hospital for at least one day, and are restricted with regards to driving and work the next day. Many patients find them unpleasant, they use a lot of resource within hospitals, and are costly to the NHS and society as a whole.This project, led by the University of Glasgow with NHS Greater Glasgow and Clyde, will more accurately predict which patients will develop new polyps in the future, by combining data about specific changes in the polyp when looking under the microscope, and by looking at the genetic mutations of the polyps. Using existing data and polyp tissue collected by the Scottish Bowel Cancer Screening Programme in NHSGGC we will develop a new tool to better predict further polyps.Overall this new tool could reduce the number of people needing repeated colonoscopy, reducing unpleasant experiences and complications, improving access to colonoscopy by reducing surveillance lists, and reducing costs to the NHS and the UK, while maintaining a safe follow up regime for patients who have had a large bowel polyp.

肠癌筛查用于在没有症状的患者中发现肠癌和称为息肉的癌前病变。筛查的目的是早期发现肠癌-使其更容易成功治疗-并通过去除癌前息肉来预防癌症。虽然英国各地的时间不同，但一定年龄的成年人被邀请提交一份邮寄粪便样本，如果检测到血液痕迹，他们将被邀请进行一项名为结肠镜检查的详细测试。在结肠镜检查中，大约每20人中就有1人被发现患有癌症，而每3人中就有1人患有息肉。尽管在初次结肠镜检查时将息肉切除，但大约一半的患者未来仍会继续发展息肉，因此要求患者将来再次进行结肠镜检查以寻找新的息肉。结肠镜检查是一种非常有效的检查方法，它可以帮助医生决定哪些患者需要进一步的结肠镜检查，以及何时需要进行结肠镜检查。然而，这些指南在预测哪些患者可能在未来形成新的息肉方面并不十分准确，并且许多接受结肠镜检查的患者并没有进一步的息肉。结肠镜检查需要患者事先服用强效泻药，并在检查过程中服用镇静剂。严重并发症的风险很小。此外，患者至少需要住院一天，第二天的驾驶和工作受到限制。许多病人觉得它们令人不快，它们占用了医院内的大量资源，对国民保健服务和整个社会来说都是昂贵的。这个项目由格拉斯哥大学与国民保健服务大格拉斯哥和克莱德领导，将更准确地预测哪些病人将来会患上新的息肉，通过结合显微镜下观察息肉的具体变化数据，通过观察珊瑚虫的基因突变。利用NHSGGC苏格兰肠癌筛查计划收集的现有数据和息肉组织，我们将开发一种新工具，以更好地预测进一步的息肉。总体而言，这种新工具可以减少需要重复结肠镜检查的人数，减少不愉快的经历和并发症，通过减少监测名单来改善结肠镜检查的可及性，并降低NHS和英国的成本，同时为患有大肠息肉的患者维持安全的随访制度。