Systematic Light Exposure Intervention for Fatigue and Cognitive Efficiency in Pediatric Brain Tumor Survivors

系统性光照干预对小儿脑肿瘤幸存者的疲劳和认知效率

基本信息

  • 批准号:
    10373350
  • 负责人:
  • 金额:
    $ 26.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-23 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Due to advances in detection and treatment, there is a rapidly increasing population of survivors of pediatric brain tumor. With increased survival rates, there is greater emphasis on managing the late effects of pediatric brain tumor. Cognitive symptoms are prevalent among survivors and are associated with poor academic achievement, vocational success, and overall quality of life. However, few interventions have been trialed to reduce cognitive symptoms. To this end, fatigue is a common late effect of brain tumor and its treatment, and it significantly reduces cognitive efficiency, including attention and speed of processing information. Among survivors, interventions that are low cost, non-pharmacological, and appropriate for self-management are highly desired but rare. Systematic bright light exposure has been shown to be effective for improving sleep and reducing fatigue among adolescent and adult patient populations, including adolescent and young adult solid tumor, and adult cancer survivors. The purpose of the proposed study is to evaluate the feasibility and preliminary effectiveness of systematic bright light exposure for reducing fatigue and improving cognitive efficiency among pediatric brain tumor survivors. Forty survivors (ages 10-18 years) will be asked to wear systematic light exposure glasses for 30 minutes upon awakening for a six week period with follow-up at 2- weeks post-intervention. Systematic bright light exposure (intervention) will be compared to dim light exposure (placebo-control). As part of this study, we focus on intervention fidelity, using an integrated app recording timing and duration of light exposure; and adverse side effects associated with light exposure. We assess preliminary outcomes associated with patient and parent-proxy reports of fatigue and cognitive efficiency using in-person and remote administration of a computerized battery. The ultimate goal of this line of research is to trial interventions that mitigate cognitive late effects to improve quality of life in pediatric brain tumor survivors. Findings from this pilot study will be used to refine the intervention and inform a larger randomized controlled trial.
项目总结/摘要 由于检测和治疗方面的进步,小儿麻痹症的幸存者人数迅速增加。 脑瘤随着生存率的提高,人们更加重视管理儿科疾病的晚期影响。 脑瘤认知症状在幸存者中普遍存在,并与学习成绩差有关。 成就,职业成功和整体生活质量。然而,很少有干预措施被试用, 减少认知症状。为此,疲劳是脑肿瘤及其治疗的常见晚期效应,而且它 显著降低认知效率,包括注意力和处理信息的速度。之间 对于幸存者,低成本、非药物和适合自我管理的干预措施是 很受欢迎但很少见系统的强光照射已被证明对改善睡眠有效 并减少青少年和成年患者人群(包括青少年和年轻人)的疲劳 实体瘤和成人癌症幸存者。拟议研究的目的是评估可行性, 系统性强光照射对减轻疲劳和改善认知能力的初步效果 儿科脑肿瘤幸存者的效率。40名幸存者(10-18岁)将被要求佩戴 在六周的时间内,在醒来后系统地暴露于光眼镜30分钟,并在2- 干预后几周。将系统性强光暴露(干预)与暗光暴露进行比较 (安慰剂对照)。作为本研究的一部分,我们使用集成的应用程序记录, 光暴露的时间和持续时间;以及与光暴露相关的不良副作用。我们评估 与患者和父母代理报告的疲劳和认知效率相关的初步结果, 亲自和远程管理计算机化电池。这项研究的最终目标是 减轻认知迟发效应以改善儿童脑肿瘤幸存者生活质量的试验干预措施。 这项试点研究的结果将用于完善干预措施,并为一项更大的随机对照研究提供信息。 审判

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

HEATHER M CONKLIN其他文献

HEATHER M CONKLIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('HEATHER M CONKLIN', 18)}}的其他基金

Systematic Light Exposure Intervention for Fatigue and Cognitive Efficiency in Pediatric Brain Tumor Survivors
系统性光照干预对小儿脑肿瘤幸存者的疲劳和认知效率
  • 批准号:
    10493438
  • 财政年份:
    2021
  • 资助金额:
    $ 26.18万
  • 项目类别:
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Low Grade Glioma
美金刚用于预防接受低级别胶质瘤颅脑放射治疗的儿科患者的认知迟发效应
  • 批准号:
    9372822
  • 财政年份:
    2017
  • 资助金额:
    $ 26.18万
  • 项目类别:
Prophylactic Multimodal Cognitive Intervention for Children with Medulloblastoma (Resubmission)
髓母细胞瘤儿童的预防性多模式认知干预(重新提交)
  • 批准号:
    8887591
  • 财政年份:
    2015
  • 资助金额:
    $ 26.18万
  • 项目类别:
Prophylactic Multimodal Cognitive Intervention for Children with Medulloblastoma (Resubmission)
髓母细胞瘤儿童的预防性多模式认知干预(重新提交)
  • 批准号:
    9109597
  • 财政年份:
    2015
  • 资助金额:
    $ 26.18万
  • 项目类别:
Working Memory Performance among Childhood Brain Tumor Survivors
儿童脑肿瘤幸存者的工作记忆表现
  • 批准号:
    7522371
  • 财政年份:
    2008
  • 资助金额:
    $ 26.18万
  • 项目类别:
Working Memory Performance among Childhood Brain Tumor Survivors
儿童脑肿瘤幸存者的工作记忆表现
  • 批准号:
    7649468
  • 财政年份:
    2008
  • 资助金额:
    $ 26.18万
  • 项目类别:

相似海外基金

Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
  • 批准号:
    10594350
  • 财政年份:
    2023
  • 资助金额:
    $ 26.18万
  • 项目类别:
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
评估集中干预措施,以解决分散环境中肺癌筛查随访依从性低的问题
  • 批准号:
    10738120
  • 财政年份:
    2023
  • 资助金额:
    $ 26.18万
  • 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
  • 批准号:
    10526768
  • 财政年份:
    2022
  • 资助金额:
    $ 26.18万
  • 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
  • 批准号:
    10701072
  • 财政年份:
    2022
  • 资助金额:
    $ 26.18万
  • 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
  • 批准号:
    10679092
  • 财政年份:
    2021
  • 资助金额:
    $ 26.18万
  • 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
  • 批准号:
    10432133
  • 财政年份:
    2021
  • 资助金额:
    $ 26.18万
  • 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
  • 批准号:
    10327065
  • 财政年份:
    2021
  • 资助金额:
    $ 26.18万
  • 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
  • 批准号:
    10377366
  • 财政年份:
    2019
  • 资助金额:
    $ 26.18万
  • 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
  • 批准号:
    10574496
  • 财政年份:
    2019
  • 资助金额:
    $ 26.18万
  • 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
  • 批准号:
    9403567
  • 财政年份:
    2017
  • 资助金额:
    $ 26.18万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了