MI-CURE Admin

MI-CURE 管理员

• 批准号: 10375150
• 负责人: MICHAEL B CHANCELLOR
• 金额: $ 23.48万
• 依托单位: WILLIAM BEAUMONT HOSPITAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10375150
• 关键词: MI; CURE; Admin

ABSTRACT The Michigan Interdisciplinary Center for Urology Research and Education (MI-CURE) seeks to develop a world-class interdisciplinary research team comprised of scientists, clinicians, biostatisticians, and engineers to provide comprehensive and innovative approaches in benign urology. As such, we have brought together exceptional investigators with diverse expertise from Beaumont Hospital/ Oakland University William Beaumont School of Medicine and Michigan State University. The overall purpose of the MI-CURE Exploratory Center is to establish strong research foundations in bladder physiology, develop an intellectual infrastructure, and expand educational and training opportunities in benign urology research. Despite decades of research, the mechanisms by which bladder fullness is sensed are still unknown. A major barrier to developing and testing novel therapies for bladder dysfunction is our lack of understanding the mechanism of how bladder fullness is sensed. Thus, the overall goal of this initial project is to understand the basis of pressure sensing and its linkage to afferent nerve activation during bladder filling, and consequently how bladder remodeling and altered bladder wall compliance during disease can impact these mechanisms. To address this significant knowledge gap, we have assembled an interdisciplinary team of experts in physiology, cell biology, fibrosis, neurourology, statistics, and clinical urology and have recruited a promising new investigator in engineering to benign genitourinary disease, Dr. Sara Roccabianca. She has unique expertise in soft tissue mechanical characterization, microstructural quantification, and mathematical modeling of soft tissues movement. In addition to the strong benign urology research program using innovative and cutting-edge approaches, MI-CURE has an exciting Educational Enrichment Program to train and mentor all levels of adult learners, from high school students to medical students, to help expand and enhance benign urology research. MI-CURE is co-directed by the established physician-scientist team of Drs. Laura Lamb and Michael Chancellor, with clear communication and coordination plans in place. Together, MI-CURE will foster successful collaborations, education initiatives, and innovative research. Funding of MI-CURE as a P20 Exploratory Center will allow us to work with the George M. O'Brien Urology Cooperative Research Centers Program and the KURe and UroEpi career development programs through joint meetings and conference calls. Our goal is to leverage our collective resources and results into well-designed, novel projects suitable for submission as future NIH Investigator-Initiated R01s. We strongly believe that the Michigan Interdisciplinary Center for Urology Research and Education program as a whole will be greater than the sum of its parts and will contribute to developing talented researchers in benign genitourinary disorders.

摘要 密歇根泌尿学研究和教育跨学科中心（MI-CURE）寻求 建立一支由科学家、临床医生、生物统计学家、 和工程师为良性泌尿外科提供全面和创新的方法。因此，我们 汇集了来自博蒙医院/奥克兰的具有不同专业知识的杰出研究人员 威廉大学博蒙医学院和密歇根州立大学。 MI-CURE探索中心的总体目标是建立强大的研究基础 在膀胱生理学方面，发展知识基础设施，扩大教育和培训 良性泌尿学研究的机会。尽管经过几十年的研究，膀胱癌的机制 感觉到的丰满度仍然是未知的。开发和测试膀胱新疗法的主要障碍 功能障碍是我们缺乏对膀胱充盈感的机制的理解。由此可见，总体 这个项目的最初目标是了解压力感知的基础及其与传入神经的联系 膀胱充盈期间的激活，以及因此膀胱重塑和改变膀胱壁 疾病期间的依从性可影响这些机制。为了弥补这一巨大的知识差距，我们 组建了一个跨学科的专家团队，包括生理学、细胞生物学、纤维化、神经泌尿学， 统计学和临床泌尿学，并招募了一个有前途的新的研究人员在工程良性 泌尿生殖系统疾病萨拉罗卡比安卡医生她在软组织机械方面拥有独特的专业知识， 软组织运动的表征、微观结构量化和数学建模。 除了强大的良性泌尿外科研究计划，采用创新和尖端的 MI-CURE有一个令人兴奋的教育充实计划，以培训和指导所有级别的 成人学习者，从高中生到医学生，帮助扩大和提高良性泌尿学 research. MI-CURE由Laura Lamb博士的医生科学家团队共同指导， 迈克尔·钱斯勒（Michael Chancellor），制定了明确的沟通和协调计划。MI-CURE将携手 促进成功的合作，教育计划和创新研究。 资助MI-CURE作为P20探索中心将使我们能够与乔治M。奥布莱恩 泌尿外科合作研究中心计划和KURe和UroEpi职业发展计划 通过联席会议和电话会议。我们的目标是利用我们的集体资源和成果 纳入精心设计的新项目，适合作为未来NIH研究者发起的R 01提交。我们 我坚信密歇根泌尿科跨学科研究和教育中心的项目 作为一个整体将大于其部分的总和，并将有助于培养有才华的研究人员 良性泌尿生殖系统疾病