Integrators of Metastatic Potential

转移潜能积分器

• 批准号: 10372682
• 负责人: Pradipta Ghosh
• 金额: $ 9.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372682
• 关键词: Automobile Driving; Back; Biochemical; Biological Assay; Biomedical Research; Breast Cancer Cell; Breast cancer metastasis; Cells; Cellular biology; Cessation of life; Complement; Data Analyses; Family; Grant; Learning; Manuscripts; Mechanics; Metastatic breast cancer; Methods; Molecular Biology; Morbidity - disease rate; Neoplasm Metastasis; Patients; Process; Publishing; Quantitative Microscopy; Research; Signal Transduction; Signaling Molecule; Solid Neoplasm; base; career; experimental study; malignant breast neoplasm; mouse model; predictive marker; skills; therapeutic target

Metastases cause major morbidities and nearly all of deaths in patients with breast cancer and other solid tumors. Our preliminary studies point to an intracellular signaling molecule, GIV, as a central determinant of metastatic potential of breast cancer cells. GIV integrates signals from multiple biochemical and mechanical inputs, placing this molecule as a central hub for key processes driving metastasis. In the parental RO1, we propose to investigate functions of GIV in breast cancer metastasis through a combination of cell-based assays and mouse models. We expect these studies to establish GIV as a potential predictive biomarker and therapeutic target for breast cancer. The research re-entry supplement will support the applicant and her return to a research career. The applicant will participate in all aspects of the proposed research, including planning experiments, analyzing data, and publishing manuscripts. She will learn new experimental methods focused on multi-scale, quantitative microscopy to complement her existing skills in cell and molecular biology. The supplement will enable the applicant to successfully transition back into a successful career in biomedical research.

转移引起了乳腺癌和其他固体疾病患者的主要发病率和几乎所有的死亡