Neurofeedback of amygdala activity for PTSD

PTSD 杏仁核活动的神经反馈

• 批准号: 10370554
• 负责人: ILAN HARPAZ-ROTEM
• 金额: $ 7.75万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-24 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10370554
• 关键词: Affect; Amygdaloid structure; Anterior; Area; Brain; Brain imaging; Clinical; Clinical Trials; Clinical assessments; Data; Disease; Ensure; Feedback; Fright; Functional Magnetic Resonance Imaging; Goals; Individual; Intervention; Investigational Therapies; Learning; Medicine; Memory; Mental Depression; Monitor; Neurobiology; Neurosciences; Patients; Pattern; Phase; Post-Traumatic Stress Disorders; Prevalence; Psyche structure; Regulation; Reporting; Research; Research Project Grants; Rest; Risk; Role; Sampling; Signal Transduction; Startle Reaction; Symptoms; Techniques; Testing; Time; Training; Translating; Trauma; Work; anxiety symptoms; associated symptom; base; cingulate cortex; clinically relevant; efficacy testing; emotion regulation; experience; improved; intervention effect; mind control; neurofeedback; neuroimaging; placebo group; post intervention; post-traumatic symptoms; reduce symptoms; relating to nervous system; response; success; symptom cluster; symptomatic improvement; tool

Abstract Neurofeedback of real-time functional magnetic resonance imaging (rt-fMRI) data is a new technique in which a specific aspect of brain function is monitored and provided as a feedback signal to the subject. The subject then practices controlling that aspect of their brain function using the feedback as a training signal. A large number of studies have reported success in training people to control their brain function via this technique. The proposed research project applies this technique to treating and studying post-traumatic stress disorder (PTSD). More specifically, the project examines whether neurofeedback of rt-fMRI data can enable individuals with PTSD to develop control over activity in a region of their amygdala involved in symptom anxiety and thereby reduce their PTSD symptoms. If so, this new technique may yield a low-risk, non-invasive clinical intervention for PTSD. In addition, patterns of resting state functional connectivity between brain areas will be examined before and after neurofeedback to determine how intrinsic brain dynamics are altered by the intervention, and how those alterations relate to changes in clinical symptoms. This will inform our understanding of the network dynamics underlying PTSD symptoms.

摘要 实时功能磁共振成像(RT-fMRI)数据的神经反馈是一种新技术，其中 大脑功能的一个特定方面被监测，并作为反馈信号提供给受试者。主题是 然后练习使用反馈作为训练信号来控制他们大脑功能的这一方面。大号 许多研究报告称，通过这项技术成功地训练了人们控制他们的大脑功能。 建议的研究项目将这项技术应用于治疗和研究创伤后应激障碍。 (创伤后应激障碍)。更具体地说，该项目考察了RT-fMRI数据的神经反馈是否能够使个人 患有创伤后应激障碍的患者可以控制杏仁核中与症状焦虑和 从而减轻他们的创伤后应激障碍症状。如果是这样的话，这种新技术可能会产生一种低风险、非侵入性的临床 对创伤后应激障碍的干预。此外，大脑区域之间的静息状态功能连接的模式将是 在神经反馈前后进行检查，以确定大脑内在动力是如何由 干预，以及这些变化与临床症状变化的关系。这将通知我们的 了解潜在的创伤后应激障碍症状的网络动态。