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Bone Health in Patients with Urinary Stone Disease

泌尿系结石患者的骨骼健康

基本信息

批准号：
10370918
负责人：
Calyani Ganesan
金额：
$ 19.4万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-15 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10370918
关键词：
Alkalies Award Biological Markers Bone Resorption Calcium Caring Citrates Clinic Clinical Clinical Investigator Collection Cross-Sectional Studies Data Data Set Detection Development Diagnosis Disease Early Diagnosis Early treatment Equilibrium Exhibits Forteo Fracture Funding Grant Guidelines Healthcare Systems Hour Hydroxyproline Hypogonadism Imaging Techniques Institutes Kidney Calculi Knowledge Measurement Measures Menopausal Status Mentored Patient-Oriented Research Career Development Award Mentorship Monitor Osteocalcin Osteogenesis Osteoporosis Osteoporotic Patient Care Patient Recruitments Patients Peripheral Persons Pharmaceutical Preparations Pharmacoepidemiology Postmenopause Provider Quality of Care Recurrence Research Research Infrastructure Research Personnel Resolution Risk Factors Scientist Serum Signal Transduction Statistical Methods Thick Time Training United States Department of Veterans Affairs Universities Urinary Calculi Urine Veterans Health Administration Vision Work X-Ray Computed Tomography bisphosphonate bone bone health bone imaging bone strength calcium metabolism clinically significant cohort comorbidity density experience fracture risk high risk imaging modality improved novel patient oriented research prevent prospective recruit screening screening guidelines skeletal skills treatment guidelines

项目摘要

Project Summary This K23 proposal will provide Calyani Ganesan, MD, MS with dedicated time, mentorship, training, and research experience to become an independent clinical investigator. Dr. Ganesan is a clinician-scientist with a long-term vision of improving the quality of care for patients with urinary stones. Under the guidance of a strong mentorship team, she will acquire skills in: 1) advanced statistical methods used in pharmacoepidemiology studies; 2) the collection and analysis of prospective patient data; and 3) a novel bone imaging technique, high-resolution peripheral quantitative computed tomography (HR-pQCT), to assess skeletal status. This grant proposes to improve the screening and management of patients with urinary stone disease and diminished bone strength. Despite an increased risk of fracture in patients with urinary stone disease, there are currently no guidelines regarding the screening and treatment of osteoporosis in these patients. It is also unclear which medications might provide dual benefit in decreasing skeletal fragility and reducing stone recurrence in these patients. This project aims to: 1) identify patients with urinary stone disease who are at high risk for osteoporosis or fracture; 2) determine the effects of medications used to treat osteoporosis on urinary stone disease; and 3) identify the underlying bone deficits in patients with urinary stone disease using HR-pQCT and bone biomarkers reflecting bone formation and resorption. The first two aims will be answered by analyzing national data from the Veterans Health Administration (VHA) and Optum datasets. For the third aim, Dr. Ganesan will recruit patients with urinary stone disease from the Stanford University and Veterans Affairs Palo Alto Health Care System Kidney Stone clinics. She will use HR-pQCT and serum biomarkers to measure and monitor bone parameters over time in these patients. The proposed work has potential to make a significant clinical impact. Successful completion will enable clinicians to identify which patients with urinary stone disease should be screened osteoporosis and inform clinicians how best to treat these patients so that fracture associated comorbidity and recurrent stones can be reduced. The proposed work is realistic and feasible within the award period, and the research infrastructure at Stanford is already in place. Dr. Ganesan is poised to build on her research skills, advance and disseminate scientific knowledge, create additional collaborative networks, and eventually compete for R01 or equivalent funding. In summary, the K23 award will provide the support to enable Dr. Ganesan to become a successful independent clinical investigator.

项目总结