Development of a novel device to improve the breast milk microbiome

开发一种改善母乳微生物组的新型装置

• 批准号: 10058431
• 金额: $ 16.45万
• 依托单位: BOOBYBIOME LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10058431
• 关键词: Development; novel; device; improve; breast

BoobyBiome is passionate about **empowering parents** and improving the **health of their babies** by designing products which support the infant microbiome. A healthy gut microbiome is crucial in regulating digestive, immune and metabolic functions. The breastmilk microbiome contributes **40%** of the first beneficial gut bacteria to infants. However current rates of breastfeeding are poor and preterm babies, C-section and formula-fed infants have reduced access to breastmilk. These babies have an **increased risk** of developing microbiome-related diseases, including necrotising enterocolitis, diabetes, IBS and obesity.BoobyBiome is currently developing a breastmilk-derived microbiome supplement for infants with compromised microbiomes. Throughout R&D, it became clear that certain breastfeeding methods diminish the **viability** of positive microbial communities in breastmilk. We are consequently implementing a multi-faceted approach to improving infant gut health, by sustaining the milk-derived bacteria that these babies are lacking.With this project, BoobyBiome will develop a **method to** **protect the breast milk microbiome** so all babies may be able to benefit from the thriving bacterial communities discussed, irrespective of how they receive their milk. We will: **1)** Develop a prototype, **2)** Conduct effective iterations of prototype testing and **3)** Finish with a patented, trademarked product with manufacturing and commercialisation mapped out for the next phase.As a team of female entrepreneurs and scientists we are well positioned to meet these deliverables. Key to milestone completion is our close association with the **academic community** and our **experienced advisory team**, including Dr. Bajaj-Elliott of the UCL Institute of Child Health.Effective, affordable access to breastmilk microbial communities allows for **all babies** to develop a healthy microbiome and every parent to provide that. BoobyBiome is committed to producing a **scientifically-valid** product that is **trusted** by parents, accessible to all babies, and which has the potential to **exert real change in the healthcare sector.**

BoobyBiome热衷于通过设计支持婴儿微生物组的产品来**增强父母**和改善婴儿**健康。健康的肠道微生物群对调节消化、免疫和代谢功能至关重要。母乳微生物群为婴儿贡献了40%的首批有益肠道细菌。然而，目前的母乳喂养率很低，早产儿、剖腹产和配方奶喂养的婴儿获得母乳的机会减少。这些婴儿患微生物相关疾病的风险增加，包括坏死性小肠结肠炎、糖尿病、肠易激综合征和肥胖症。BoobyBiome目前正在开发一种母乳来源的微生物组补充剂，用于微生物组受损的婴儿。在整个研发过程中，很明显，某些母乳喂养方法会降低母乳中阳性微生物群落的生存能力。因此，我们正在实施一种多方面的方法来改善婴儿肠道健康，通过维持这些婴儿所缺乏的牛奶衍生细菌。在这个项目中，BoobyBiome将开发一种方法** **保护母乳微生物群**，这样所有的婴儿都能从讨论的蓬勃发展的细菌群落中受益，无论他们是如何获得母乳的。我们将：**1)**开发原型，**2)**进行有效的原型测试迭代，**3)**完成专利和商标产品，并为下一阶段的生产和商业化制定计划。作为一个由女性企业家和科学家组成的团队，我们完全有能力实现这些成果。完成里程碑的关键是我们与**学术界**和我们**经验丰富的咨询团队**的密切联系，包括伦敦大学学院儿童健康研究所的Bajaj-Elliott博士。有效、负担得起的母乳微生物群落可使**所有婴儿**形成健康的微生物群，而每位父母都应提供这种微生物群。BoobyBiome致力于生产**科学有效的**产品，**信任**，所有婴儿都可以使用，并有可能**在医疗保健领域产生真正的变化**