University of Pittsburgh MACS/WIHS CCS

匹兹堡大学 MACS/WIHS CCS

• 批准号: 10376144
• 负责人: Jeremy James Martinson
• 金额: $ 406.41万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376144
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adult; Affect; Age; Aging; Anatomy; Anti-Retroviral Agents; Applications Grants; Back; Behavior; Behavioral; Biological; Blood; Body Composition; Brain; Brain imaging; CD4 Positive T Lymphocytes; Cancer Survivorship; Cardiac; Cardiovascular system; Cells; Censuses; Cessation of life; Characteristics; Chronic; Clinical; Clinical Management; Clonal Expansion; Cognition; Cognitive; Cohort Studies; Collection; Complement; County; Data; Development; Drug Exposure; Education; Elderly; End stage renal failure; Enrollment; Epidemic; Epidemiology; Event; Feces; Female; Fostering; Fracture; Funding; Genetic; Genome; Guidelines; HIV; HIV Infections; Hair; Health; Immune; Immunologics; Immunosuppression; Incidence; Income; Inequality; Infrastructure; Intervention; Irrigation; LIF gene; Laboratories; Lead; Leadership; Life; Location; Lung; Lung diseases; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Metabolic; Methods; Mission; Natural History; Neighborhoods; Neurocognitive; Ohio; Oral; Oral health; Outcome; Outcome Measure; Participant; Pathogenesis; Pattern; Persons; Pharmacology; Phenotype; Physical Function; Plasma; Population; Poverty; Prevention; Protocols documentation; Race; Request for Applications; Research; Research Personnel; Research Project Grants; Respiratory Signs and Symptoms; Risk; Risk Factors; Role; Sleep; Specimen; Standardization; Stroke; Structure; Students; The Multicenter AIDS Cohort Study; Tissues; Tumor Tissue; United States; Universities; Urine; Viral Load result; Viral reservoir; Virus Latency; Woman; Women' s Interagency HIV Study; adjudicate; cancer therapy; career; career development; cervicovaginal; clinical research site; co-infection; cognitive function; cohort; comorbidity; disability; falls; frailty; health disparity; improved; innovation; insight; interest; male; men; men who have sex with men; microbiome; molecular marker; mortality; neuroimaging; novel; older men; older women; prevent; psychosocial; pulmonary function; resilience; sex; sleep quality

PROJECT SUMMARY/ABSTRACT The overarching strategy of the University of Pittsburgh (Pitt) clinical research site (CRS) together with our collaborative clinical site at The Ohio State University (OSU) of the Multicenter AIDS Cohort Study (MACS)/Woman’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS CCS) is to support, complement and accelerate the CCS unified scientific agenda (USA) by leveraging the strengths and scientific expertise of CRS investigators. We propose to continue to expand on our 35 years of extensive research on the natural history of HIV infection. The central hypothesis of this grant application is that, as men and women with chronic HIV infection age, they increase their risks for serious, life-shortening comorbidities beyond those of comparable age, uninfected persons, and this could differ between men and women. As directed by NIH RFA- HL-19-008, the CRS will provide robust and inclusive leadership focused on five specific aims of the USA, and targeted collaborative support for the five other aims, to improve our understanding of the epidemiologic, clinical, virologic, immunologic, and behavioral relationships of HIV infection to chronic comorbidities in men and women that represent the current HIV epidemic in the United States. The CRS will also contribute longitudinal data and biological specimens for collaborative research projects on HIV led by CCS and non-CCS investigators. This research is important to fulfill our mission of improving clinical management, increasing survival and controlling, preventing and curing HIV infection. The CRS will provide the most current and innovative epidemiological, clinical and laboratory methods and psychosocial research protocols to accomplish our 5 leadership specific aims. The Pitt/OSU CRS will be led by a triumvirate of MPIs and several CoIs with broad expertise needed to lead five highly specialized CCS USA Specific Aims (Aim 2: Pulmonary/Sleep [Morris]; Aim 3: Neurocognitive [Becker]; Aim 6: HIV/Pathogenesis [Macatangay]; Aim 7: Psychosocial [Stall]; Aim 9: Platform [Rinaldo, Kingsley]) and to provide insight for the 5 other Specific Aims (Aim 1: Cardiovascular [Kingsley, Martinson], Aim 4: Aging [Koletar], Aim 5: Cancer [Jenkins], Aim 8: Health Disparities [Krier], Aim 10: Career Development [Sluis- Cremer]. With this plan the Pitt/OSU CRS addresses the basic justification of the FOA, i.e., that the impact of HIV, its treatment, and the legacy of immune suppression need to be more fully understood to optimize the health of people living with HIV.

项目总结/摘要 匹兹堡大学（皮特）临床研究中心（CRS）的总体战略与我们的 俄亥俄州州立大学（OSU）多中心艾滋病队列研究的合作临床研究中心 （MACS）/妇女机构间艾滋病毒研究（WIHS）联合队列研究（MACS/WIHS CCS）是为了支持， 补充和加速CCS统一科学议程（美国）， CRS调查员的专业知识。我们建议继续扩大我们35年的广泛研究 HIV感染的自然史。这项拨款申请的中心假设是，作为男性和女性， 慢性艾滋病毒感染年龄，他们增加了严重的，缩短寿命的合并症的风险， 年龄相仿，未感染者，这可能在男性和女性之间存在差异。根据NIH RFA的指示， HL-19-008，CRS将提供强大和包容性的领导，重点是美国的五个具体目标， 有针对性的合作支持其他五个目标，以提高我们对流行病学，临床， HIV感染与男性和女性慢性合并症的病毒学、免疫学和行为学关系 代表了目前美国艾滋病的流行。CRS还将提供纵向数据， 由CCS和非CCS研究人员领导的艾滋病毒合作研究项目的生物标本。这 研究对于实现我们的使命是重要的，我们的使命是改善临床管理，提高生存率和控制， 预防和治疗HIV感染。CRS将提供最新和最具创新性的流行病学， 临床和实验室的方法和心理社会研究协议，以完成我们的5个领导具体 目标。皮特/俄勒冈州立大学CRS将由三人制的MPI和几个具有广泛专业知识的CoI领导， 导致五个高度专业化的CCS USA特定目标（目标2：肺/睡眠[Morris];目标3：神经认知 [Becker];目标6：HIV/发病机制[Macatangay];目标7：心理社会[Stall];目标9：平台[Rinaldo， Kingsley]），并为其他5个特定目标（目标1：心血管[Kingsley，Martinson]，目标 4：衰老[Koletar]，目标5：癌症[Jenkins]，目标8：健康差距[Krier]，目标10：职业发展[Sluis- Cremer]。有了这个计划，皮特/俄勒冈州立大学CRS解决了FOA的基本理由，即，的冲击 艾滋病毒，其治疗和免疫抑制的遗产需要更充分地了解，以优化健康 艾滋病病毒携带者。