ETHEREAL: EPIGENETIC-GENETIC-MENTAL HEALTH CASCADE BASED PERSONALISED PREVENTION OF NONCOMMUNICABLE DISEASE IN ADOLESCENTS DIAGNOSED WITH AUTISM

ETHEREAL：基于表观遗传-遗传-心理健康级联的个性化预防自闭症青少年非传染性疾病

• 批准号: 10060207
• 金额: $ 231.27万
• 依托单位: UNIVERSITY OF SOUTHAMPTON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10060207
• 关键词: ETHEREAL; EPIGENETIC; GENETIC; MENTAL; HEALTH

Five Noncommunicable Diseases (NCD) – diabetes, cardiovascular disease, cancer, chronic respiratory disease and Mental Health Disorders (MHD) – account for 86% deaths and 77% disease burden in the WHO Europe region. Of these five NCDs, MHD is unique as it has a complex bi-directional relationship with the other four major NCDs, meaning that, on one hand, it could be the initiator of the other NCDs, or other NCDs could lead to MHD which, in turn, can further aggravate the primary NCD leading to a vicious circle. Recent research identified MHD as the highest ranked NCD in adolescent population. A specific group in this population that is 3 - 6 times more vulnerable for developing MHD and subsequent NCD is the adolescents diagnosed with Autism Spectrum Disorders (ASD). There is no Evidence Based Intervention (EBI) for preventing MHD in an ASD adolescent since 1) the major risk factors are in-grained in their biological process and 2) they present with multiple MHD comorbidity. Personalisation is the key to prevent their already vulnerable mental states making transition to an MHD - "which" EBI is appropriate for "which" ASD adolescent and "how" to choose it - an unsolved question. Because of their neurobiological characteristics, personalisation must be done at biological level. Recent research showed how the environmental factors can alter gene expressions that leads to an MHD through Epigenetic-Genetic/metabolomic Mental health (EGM) process. Using quantitative modelling of this process, ETHREAL will develop a personalised, flexible, single service delivery model that will empower an ASD adolescent to self-control their environmental factors while seamlessly accessing the community care services to prevent their mental health making transition to an MHD - a unique solution for sustainable prevention of MHD and subsequent NCDs in this population. Without loss of generality, the proposed solution could be adapted to prevent MHD in wider adolescent population

五种非传染性疾病（NCD）-糖尿病，心血管疾病，癌症，慢性呼吸道疾病和精神卫生障碍（MHD）-占世卫组织欧洲区域死亡人数的86%和疾病负担的77%。在这五种NCD中，MHD是独特的，因为它与其他四种主要NCD具有复杂的双向关系，这意味着，一方面，它可能是其他NCD的引发者，或者其他NCD可能导致MHD，反过来，MHD可以进一步加重原发性NCD，导致恶性循环。最近的研究将MHD确定为青少年人群中排名最高的NCD。在这一人群中，一个特定的群体是3 - 6倍更容易发展MHD和随后的NCD是诊断为自闭症谱系障碍（ASD）的青少年。目前尚无预防ASD青少年MHD的循证干预措施（EBI），因为1）主要风险因素在其生物学过程中根深蒂固，2）他们存在多种MHD合并症。个性化是防止他们已经脆弱的精神状态过渡到MHD的关键-“哪种”EBI适合“哪种”ASD青少年以及“如何”选择它-这是一个未解决的问题。由于它们的神经生物学特征，个性化必须在生物学水平上完成。最近的研究表明，环境因素如何改变基因表达，导致MHD通过表观遗传/代谢组学心理健康（EGM）过程。使用这一过程的定量模型，ETHREAL将开发一种个性化，灵活，单一的服务提供模式，使ASD青少年能够自我控制他们的环境因素，同时无缝地获得社区护理服务，以防止他们的心理健康过渡到MHD -这是可持续预防MHD和随后的NCD的独特解决方案。不失一般性，建议的解决方案可适用于在更广泛的青少年人群中预防MHD