Clinical & Translational Tools and Resources (CTTR) Core
临床
基本信息
- 批准号:10381594
- 负责人:
- 金额:$ 34.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-02 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AgreementAmericanBehavior assessmentBehavioralBiological MarkersBiologyBiometryBiostatistical MethodsBrainCell NucleusCenters of Research ExcellenceCharacteristicsClinicalClinical DataClinical ResearchClinical TrialsCollaborationsCommunitiesComputerized Medical RecordConsentDataData AnalysesData LinkagesData SetData SourcesData StoreDatabasesDelawareDevelopmentEnsureExperimental DesignsFeasibility StudiesFundingFutureGenerationsGlossaryGoalsGuidelinesHealthHealth OccupationsHealth SciencesHeartHomeHospitalizationHumanImageImpairmentIndividualInformaticsInfrastructureInternationalInterventionLeadLinkLocationMagnetic Resonance ImagingManualsManuscriptsMeasuresMedical HistoryMentorsMethodologyMiningNational Institute of Neurological Disorders and StrokeNatureNeuromechanicsNeuronal PlasticityOccupational TherapistOccupational TherapyOutcome MeasureParticipantPatient RecruitmentsPhasePhysical therapyPoliciesPopulationPositioning AttributeProductivityProtocols documentationRecontactsRecordsRegistriesRehabilitation therapyReliability of ResultsResearchResearch InstituteResearch PersonnelResourcesRoleSecureSeriesSourceSouth CarolinaStrokeStructureSumSystemTestingTimeTranscranial magnetic stimulationTranslatingTranslational ResearchValidationacronymsanalysis pipelinearchive databasebehavior measurementbiomedical informaticsbiomedical information systemclinical data warehouseclinical databasecollegedata archivedata exchangedata integrationdata miningdata reusedata sharingdesigndisabilityelectronic dataexperienceexperimental analysisfunctional MRI scangait examinationimprovedinformatics infrastructureinformatics toolinterestmeetingsmembermultidisciplinaryneuroimagingneurophysiologyneuroregulationnovelphysical therapistpost strokeprogramsprospectiverecruitresearch studyskillssoundstroke recoverytheoriestooltranslational study
项目摘要
The Clinical & Translational Tools and Resources Core (CTTR) is designed to serve the clinical research needs
of COBRE investigators. The centerpiece of the core will be a powerful new research tool, the Stroke
Comprehensive Multidisciplinary Database (CMD). In addition to containing information such as stroke type and
disability status necessary to recruit participants, which comes from the registry established in Phase I called
RESTORE (REgistry for STrOke REcovery), the CMD will be the home of all data produced when an individual
participates in any research study/ies within the COBRE domain. For example, the CMD will include outcome
measures extracted from the data sets collected in the QBAR Core as well as the complete data time series
(e.g., neuromechanical data from behavioral measurements such as gait analyses, neurophysiological data from
transcranial magnetic stimulation protocols in the Brain Stimulation Core, and neuroimaging data from structural
or functional MRI scans in the Neuroimaging Core). The CMD will be a secure, query-enabled research portal
with vast capacity for data sharing accessible to all COBRE investigators. Through a robust interface with the
South Carolina Clinical & Translational Research Institute (SCTR), CTTR has four complementary roles that
represent the core aims: 1) Recruitment & Retention – recruit a large population of well-characterized potential
participants; 2) Biomedical Informatics – continue to develop a secure registry and database providing the ability
to query the pool of participants based on specific characteristics and retrieve an extensive set of multidisciplinary
measures in participants who match the search criteria; 3) Biostatistical Support – provide a strong biostatistical
infrastructure to analyze and mine the rich data set and support experimental design and data analysis; and (4)
Mentoring – enhance the research skills of COBRE investigators to conduct highly translational, mechanism-
based studies in stroke recovery research and neuromodulation. COBRE funds will support the efforts of an
internationally recognized clinician-researcher in the stroke field who serves as Core Director; an expert in
biomedical informatics who oversees the informatics infrastructure; an expert in biostatistical methodologies and
clinical trials development; and technical staff. The SCTR Research Coordinator Core will facilitate research
coordination and recruitment. The integration of multi-source data into the CMD with advanced informatics tools
and biostatistical analyses will provide a unique research resource for future stroke recovery research by: 1)
enabling advanced searches for appropriate candidates for each scientific study by specific characteristics; 2)
providing an avenue for data mining for manuscripts and pilot data generation to increase investigator and trainee
productivity; and 3) embedding biostatistical and data analysis expertise throughout the CMD analyses pipelines.
We envision that CMD will be a unique research resource for MUSC, South Carolina, and all members of the
research and public communities with interest in stroke recovery.
临床与转化工具和资源核心(CTTR)是为满足临床研究需求而设计的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ROBERT J ADAMS', 18)}}的其他基金
DISPLACE: Dissemination and Implementation of Stroke Prevention Looking at the Care Environment
DISPLACE:从护理环境来看中风预防的传播和实施
- 批准号:
10210281 - 财政年份:2017
- 资助金额:
$ 34.74万 - 项目类别:
DISPLACE: Dissemination and Implementation of Stroke Prevention Looking at the Care Environment
DISPLACE:从护理环境来看中风预防的传播和实施
- 批准号:
9925881 - 财政年份:2017
- 资助金额:
$ 34.74万 - 项目类别:
Clinical and Translational Tools and Resources Core
临床和转化工具和资源核心
- 批准号:
8663382 - 财政年份:2014
- 资助金额:
$ 34.74万 - 项目类别:
Hydroxyurea to Prevent CNS Complications of Sickle Cell Disease in Children
羟基脲预防儿童镰状细胞病中枢神经系统并发症
- 批准号:
8322635 - 财政年份:2011
- 资助金额:
$ 34.74万 - 项目类别:
Prevention of Stroke after STOP, A Retrospective Chart Review
停止后预防中风,回顾性图表回顾
- 批准号:
7922143 - 财政年份:2009
- 资助金额:
$ 34.74万 - 项目类别:
Prevention of Stroke after STOP, A Retrospective Chart Review
停止后预防中风,回顾性图表回顾
- 批准号:
7699050 - 财政年份:2009
- 资助金额:
$ 34.74万 - 项目类别:
Prevention of Stroke after STOP, A Retrospective Chart Review
停止后预防中风,回顾性图表回顾
- 批准号:
8292038 - 财政年份:2009
- 资助金额:
$ 34.74万 - 项目类别:
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