Unlocking discovery of next-generation multispecific biologics for targeted cancer therapies

单抗已经成为晚期癌症的治疗标准；然而，耐药性(无论是原发的还是获得性的)是一个主要问题。单特异性抗体的临床疗效仍然有限，特别是在晚期实体瘤的情况下。多特异性生物制剂在克服单特异性抗体的治疗缺点方面显示出巨大的前景。由于结合位点针对多个信号通路，多特异性抗体降低了原发或获得性耐药的可能性，并提高了临床疗效，预防和/或延缓了发病。最重要的是，多特异性生物制剂使消除癌细胞的新作用机制成为可能，这是传统抗体无法实现的。到目前为止，已有7种双特异性抗体获得市场批准，50多种处于临床试验中。然而，由于缺乏高通量的多特异性组装和筛选技术，多特异性生物制品的发现仍然受到严重限制。由于潜在目标的数量、组合结合/格式空间以及复杂(通常未知)的作用机制，多特异性的发现变得更加复杂。LiliumX是一家总部位于英国的初创企业(SME)，于2021年从牛津大学剥离出来，由Arne Scheu和Irsyad Khairil博士共同创立。我们已经开发了一种变革性的专有平台技术，用于高通量组装和筛选多特定生物制剂。我们已经从Y组合体和创造性销毁实验室毕业，提交了保护我们的通用组装平台的专利申请，并从领先的风险投资家那里筹集了投资。在Smart Funding的帮助下，我们将进一步开发和验证我们的通用组装平台的性能，以发现多个特定的生物制剂，展示我们可以创造可行的资产，通过从发现到体内研究的管道。50年来，英国在开发单抗药物方面一直处于世界领先地位。Innovate UK Smart Funding开发和验证LiliumX的通用组装平台将使英国在未来50年处于领先地位，开发下一代多特定生物制品并将其商业化。

Monoclonal antibodies have emerged as the Standard of Care for late-stage cancers; however, resistance (whether primary or acquired) is a major issue. Clinical efficacy of monospecific antibodies remains limited, particularly in the case of advanced solid tumours.Multispecific biologics show great promise in overcoming the treatment shortcomings of monospecific antibodies. With binding sites targeting multiple signalling pathways, multispecific antibodies decrease the likelihood of primary or acquired resistance and increase clinical efficacy, preventing and/or delaying pathogenesis. Most importantly, multispecific biologics enable new mechanisms of action to eradicate cancer cells, not otherwise possible with traditional antibodies. To date, seven bispecific antibodies have received market approval and over 50 are in clinical trials.However, the discovery of multispecific biologics remains severely restricted by the lack of high-throughput assembly and screening technologies for multispecifics. Discovery of multispecifics is further complicated by the number of potential targets, combinatorial binder/format spaces, and complex (often unknown) mechanisms of action.LiliumX is a UK-based start-up (SME), spun out from the University of Oxford in 2021, co-founded by Drs Arne Scheu and Irsyad Khairil. We have developed a transformative and proprietary platform technology for high-throughput assembly and screening of multispecific biologics. We have graduated from Y Combinator and Creative Destruction Lab, filed a patent application to protect our Universal Assembly Platform, and raised investment from leading venture capitalists.With Smart funding, we will further develop and validate the performance of our Universal Assembly Platform for multispecific biologics discovery, demonstrating that we can create viable assets, through the pipeline from discovery to _in vivo_ studies.For 50 years, the UK has led the world in developing monoclonal antibody drugs. Innovate UK Smart funding to develop and validate LiliumX's Universal Assembly Platform will position the UK to lead the way for the next 50 years, developing and commercialising next-generation multispecific biologics.