Development of Molecular Microbubble Probes and Ultrasound-Guidance in Immunotherapeutic Strategies
免疫治疗策略中分子微泡探针和超声引导的发展
基本信息
- 批准号:10383730
- 负责人:
- 金额:$ 7.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAbdomenAddressAdoptedAdverse effectsAdverse eventAngiogenesis InhibitorsBindingBiological MarkersBlood VesselsCell Surface ReceptorsCell surfaceCellsClinicClinicalClinical TrialsColorectalCombined Modality TherapyComplementComplexContrast MediaDevelopmentDoseEndothelial CellsEndotheliumEngineeringEvaluationEventFDA approvedFeedbackGoalsHepatic MassImageImmuneImmune checkpoint inhibitorImmune systemImmunityImmunohistochemistryImmunologic MarkersImmunosuppressionImmunotherapeutic agentImmunotherapyImplantIn VitroInfiltrationKineticsLifeLiverMalignant NeoplasmsMalignant neoplasm of liverMeasurementMetastatic Neoplasm to the LiverMicrobubblesMolecularMusNational Institute of Biomedical Imaging and BioengineeringNatureNeoplasms in Vascular TissueOutcomePatientsPerfusionPhenotypePropertyReceptor CellResearchRodentSampling ErrorsSpecificitySurfaceTherapeuticTissue imagingTissuesToxic effectTranslationsTreatment ProtocolsUltrasonographyVariantVascular Endothelial CellVascular Endotheliumanergyanticancer activitybasecancer imagingcellular imagingcostdesigneffector T cellhistological studiesimage guidedimaging approachimaging modalityimaging probeimmune activationimmune checkpointimmune imagingimprovedin vivomolecular imagingmultiparametric imagingnon-invasive imagingpatient responsepredicting responsepredictive markerprogrammed cell death ligand 1programsquantitative ultrasoundresponseserial imagingsuccesstargeted agenttooltreatment effecttreatment responsetumortumor growthultrasoundvascular abnormality
项目摘要
PROJECT SUMMARY/ABSTRACT
Despite the unprecedented effects of immunotherapy in treating cancer, over 50–80% of patients will not
respond to treatment and will endure severe adverse and life-threatening events due to treatment. Approaches
to select or guide immunotherapeutic strategies are urgently needed. We propose to develop ultrasound-based
approaches to characterize an overlooked attribute of tissue immuno-imaging; the vasculature and associated
endothelium. In cancer, tumor blood vessels and associated endothelial cells are highly abnormal and
immunosuppressive. These also differ extensively on a patient-by-patient basis. Approaches to modulate
vascular and endothelial immunity have been developed, where anti-angiogenic agents are used to directly
target these and enhance the effects of immunotherapy. However, timing and dosing of anti-angiogenics with
immunotherapy remains a major challenge to maximize benefits to all patients. As such, the tools we propose
to develop will help 1) select patients that are most likely to respond to immunotherapy and reduce adverse
effects and costs to non-responders, and 2) provide imaging feedback for guiding combined anti-angiogenic
and immunotherapy treatment regimens so that more patients may benefit from the unparalleled effects of
these treatments. In order to achieve our goals, we will: 1) develop unique molecular ultrasound probes for
imaging endothelial cell immunosuppressive surface markers, and 2) develop image-guidance to optimize
immunotherapeutic strategies by exploring the quantitative ultrasound parameter space. Equipped with these
initial developments, our goal will be to initiate a larger research program designed to further develop
quantitative ultrasound approaches for imaging tissue, vascular and endothelial aspects of the immune system.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Ahmed El Kaffas其他文献
Ahmed El Kaffas的其他文献
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{{ truncateString('Ahmed El Kaffas', 18)}}的其他基金
Novel Mechano-Acoustic Enhancement of Immunotherapy
免疫治疗的新型机械声增强
- 批准号:
10544783 - 财政年份:2022
- 资助金额:
$ 7.93万 - 项目类别:
Novel Mechano-Acoustic Enhancement of Immunotherapy
免疫治疗的新型机械声增强
- 批准号:
10372815 - 财政年份:2022
- 资助金额:
$ 7.93万 - 项目类别:
Development of Molecular Microbubble Probes and Ultrasound-Guidance in Immunotherapeutic Strategies
免疫治疗策略中分子微泡探针和超声引导的发展
- 批准号:
10057655 - 财政年份:2020
- 资助金额:
$ 7.93万 - 项目类别:
Development of Molecular Microbubble Probes and Ultrasound-Guidance in Immunotherapeutic Strategies
免疫治疗策略中分子微泡探针和超声引导的发展
- 批准号:
10192718 - 财政年份:2020
- 资助金额:
$ 7.93万 - 项目类别:
Three-Dimensional Multi-Parametric Ultrasound for Monitoring Therapy of Liver Metastasis
三维多参数超声监测肝转移治疗
- 批准号:
10456333 - 财政年份:2016
- 资助金额:
$ 7.93万 - 项目类别:
Three-Dimensional Multi-Parametric Ultrasound for Monitoring Therapy of Liver Metastasis
三维多参数超声监测肝转移治疗
- 批准号:
10680583 - 财政年份:2016
- 资助金额:
$ 7.93万 - 项目类别:
Three-Dimensional Multi-Parametric Ultrasound for Monitoring Therapy of Liver Metastasis
三维多参数超声监测肝转移治疗
- 批准号:
10299426 - 财政年份:2016
- 资助金额:
$ 7.93万 - 项目类别:
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