Manufacturing high purity mRNA at significantly reduced cost

目前mRNA药物是通过体外转录（IVT）反应合成的。双链RNA （dsRNA）的存在是mRNA药物的主要质量问题之一。此外，IVT反应的原料成本很高，但利用效率很低。该合作研究项目旨在使用更具成本效益的试剂，并通过创新的纯化方法回收大部分试剂，以更短的加工步骤和显著降低制造成本产生高纯度的mRNA。

Currently mRNA medicines are synthesized through in vitro transcription (IVT) reaction. The presence of double-stranded RNA (dsRNA) is one of the major quality concerns to mRNA medicines. Besides, the raw material cost in IVT reactions is very high but their utilisation efficiency is very low. This collaborative research project aims to use more cost-effective reagents and recycle most reagents through innovative purification methods to generate high purity mRNA at shorter processing steps and at significantly reduced manufacturing cost.