Bacterial cell invasion factors as vaccine targets

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This project aims to determine the virulence factors responsible for cellular invasion and systemic spread of Mycoplasma bovis, and use genome editing technologies (CRISPR-Cas9) to create gene knock out mutants that cannot invade host cells and test their potential as vaccine candidates in animals. Mycoplasma bovis is an emerging cause of mastitis, the most important infectious disease in the dairy industry, and causes significant economic losses. The vaccine candidates developed in this project are expected to be used to control outbreaks of mastitis, and to improve biosecurity, production and animal welfare in the Australian and global dairy industries.