Adapting and Pilot Testing a Behavioral Intervention to Incorporate Advances in HIV Prevention for Black Young MSM in Alabama

调整和试点测试行为干预措施，以纳入阿拉巴马州黑人青年 MSM 的艾滋病毒预防进展

• 批准号: 10392948
• 负责人: Henna Budhwani
• 金额: $ 4.03万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-08 至 2022-08-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392948
• 关键词: AIDS prevention; AIDS/HIV problem; Acute; Address; Adolescent Medicine Trials Network; Age; Alabama; Attention; Awareness; Behavior Therapy; Belief; Black race; Brothers; Clinic Visits; Clinical; Code; Color; Communities; Country; Data; Data Analyses; Deep South; Development; Doctor of Philosophy; Education; Effectiveness; Environment; Epidemic; Focus Groups; Funding; Goals; HIV; HIV Infections; HIV risk; Health; Home; Human immunodeficiency virus test; Hybrids; Infection; Infrastructure; Institution; Intervention; Interview; Knowledge; Learning; Link; Mentored Research Scientist Development Award; Mentors; Methods; Midwestern United States; Modeling; Modernization; Morbidity - disease rate; Outcome; Participant; Perception; Persons; Pilot Projects; Population; Positioning Attribute; Prevention education; Process; Public Health; Qualitative Methods; Qualitative Research; Randomized; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Savings; Scientist; Stigmatization; Subgroup; Target Populations; Testing; Time; Training; United States; Universities; Update; Work; acceptability and feasibility; base; brief intervention; effectiveness implementation trial; effectiveness testing; eligible participant; experience; health disparity; implementation context; implementation science; intersectionality; intervention effect; intervention mapping; member; men who have sex with men; minority children; mortality; outreach; peer; pilot test; pilot trial; pre-exposure prophylaxis; prevention service; racial minority; rapid testing; research study; same sex behavior; skills; social; social stigma; social structure; success; testing services; theories; therapy development; tool; transgender women; transmission process; trial design; young men who have sex with men

PROJECT SUMMARY The overall goal of this 5-year Mentored Research Scientist Development K01-Award is to support Henna Budhwani, PhD, MPH become an independent investigator in the field of HIV prevention. The proposed project seeks to address the HIV crisis in Alabama, where rates of undiagnosed HIV in black young men who have sex with men (YMSM, 18-29 years) exceed 20%. This project will adapt and test a behavioral intervention to promote HIV rapid testing in the community, deliver culturally appropriate prevention education, offer sociostructural supports, and refer eligible participants for pre-exposure prophylaxis (PrEP). Four training objectives are proposed that are in lockstep with three specific aims. Objective 1 includes an intensive training and mentoring plan in social theory including theories of intersectionality and emerging masculinities. Objective 2 includes in- depth training on qualitative research methods including how to conduct focus groups, in-depth interviews, and qualitative data analysis. Aim 1, which will be conducted after Objective 2, is to elucidate experiences, beliefs, and predictors related to delivery and utilization of HIV testing and prevention services by black YMSM using qualitative research methods, namely in-depth interviews with HIV outreach staff, focus groups with black YMSM, and in-depth interviews with members of key sub-groups (e.g. transgender women) to inform the adaptation of the Brothers Saving Brothers (BSB) intervention. Objective 3 includes didactic and hands-on training on how to scientifically adapt HIV behavioral interventions using validated frameworks, such as intervention mapping. Aim 2 is to adapt the BSB intervention to include two HIV prevention tools (rapid testing and PrEP), to address structural barriers, and to be acceptable to black YMSM in Alabama. Objective 4 includes comprehensive training and mentoring in the field of implementation science. Aim 3, which concludes the proposed research study and K01 project, is to conduct a hybrid type 1 effectiveness-implementation pilot study of the adapted intervention in which the candidate will a) assess acceptability and feasibility of adapted BSB (aBSB); b) preliminarily estimate effects on HIV prevention outcomes; and c) collect data on real-world implementation. These aims will be accomplished by collaborating with two community-based organizations that are well-respected for their HIV prevention work in study communities. This rigorous project includes intensive training at the candidate's home university, the University of Alabama at Birmingham (UAB) and from other prominent institutions that offer very specific training not found at UAB; engagement within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN); comprehensive mentoring from senior HIV researchers with expertise in minority, youth, and MSM health; and a thoughtful research strategy that addresses significant threats, high rates of undiagnosed HIV and insufficient engagement with HIV prevention services, including PrEP, in black YMSM in Alabama. The combination of the proposed mentoring and training with study findings will culminate in the candidate's attainment of independence and development of a full-scale, implementation science R01 proposal to test aBSB.

项目摘要 这个为期5年的指导研究科学家发展K 01奖的总体目标是支持海娜 Budhwani博士，公共卫生硕士成为艾滋病毒预防领域的独立调查员。拟建项目 旨在解决亚拉巴马的艾滋病毒危机，那里发生性行为的黑人年轻男子中未确诊的艾滋病毒感染率 男性（YMSM，18-29岁）超过20%。该项目将调整和测试行为干预，以促进 在社区进行艾滋病毒快速检测，提供文化上适当的预防教育， 支持并推荐符合条件的参与者进行暴露前预防（PrEP）。四个培训目标是 提出了与三个具体目标步调一致。目标1包括强化培训和辅导 计划在社会理论，包括理论的交叉性和新兴的男子气概。目标2包括： 定性研究方法的深入培训，包括如何进行焦点小组、深入访谈和 定性数据分析。目标1将在目标2之后进行，目的1是阐明经验、信念、 和预测有关的交付和利用艾滋病毒检测和预防服务的黑人YMSM使用 定性研究方法，即深入采访艾滋病毒外展工作人员，重点小组与黑人YMSM， 并与主要分组成员（如变性妇女）进行深入访谈， 兄弟拯救兄弟（BSB）目标3包括教学和实践培训，说明如何 科学地调整艾滋病毒行为干预措施，使用有效的框架，如干预映射。目的 2是调整BSB干预措施，包括两种艾滋病毒预防工具（快速检测和PrEP），以解决 结构性障碍，并接受黑人YMSM在亚拉巴马。目标4包括全面培训 在实施科学领域提供指导。目标3，总结了拟议的研究， K 01项目，是对适应性干预措施进行混合1型有效性-实施试点研究， 候选人将a）评估适应性BSB（aBSB）的可接受性和可行性; B）初步估计 对艾滋病毒预防成果的影响;以及c）收集关于实际执行情况的数据。这些目标将是 这是通过与两个社区组织合作完成的，这两个组织因其艾滋病毒感染而备受尊重。 研究社区的预防工作。这个严格的项目包括在候选人家中进行强化训练 大学，亚拉巴马大学伯明翰分校（UAB）和其他著名的机构，提供非常 在UAB没有具体的培训;参与艾滋病毒/艾滋病青少年医学试验网络 干预措施（ATN）;由具有少数民族、青年、 和男男性接触者的健康;和一个深思熟虑的研究战略，解决重大威胁，高比率的未确诊 在亚拉巴马的黑人YMSM中，艾滋病毒和艾滋病毒预防服务（包括PrEP）的参与不足。的 建议的指导和培训与研究结果相结合，将最终在候选人的 实现独立性，并制定全面的实施科学R 01提案，以测试aBSB。