权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

FastMOT - Fast gated superconducting nanowire camera for multi-functional optical tomograph

FastMOT - 用于多功能光学断层扫描的快速门控超导纳米线相机

基本信息

批准号：
10063660
负责人：
金额：
$ 57.75万
依托单位：
UNIVERSITY COLLEGE LONDON
依托单位国家：
英国
项目类别：
EU-Funded
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=10063660
关键词：
FastMOT Fast gated superconducting nanowire

项目摘要

Traditionally, monitoring of organs and deep body functional imaging is done by ultrasound, X-Rays (incl CT), PET or MRI. These techniques only allow for very limited measurements of functionality, usually combined with exogenous and radioactive agents. In this project we propose an innovative light sensing solution, a fast gated, ultra-high quantum efficiency single-photon sensor, to enable multi-functional deep body imaging with diffuse optics. The new type of sensor is based on superconducting nanowire single-photon detectors, that have shown to be ultra-fast and highly efficient. However, until now the active area and number of pixels has been limited to micrometers diameter and tens of pixels. We propose the combination of two new readout techniques, optical gating and charge coupling, to overcome this limit and scale to 10,000 pixels and millimeter diameter. In addition we will develop new strategies for performing TD-NIRS and TD-SCOS to use this new light sensor optimally with Monte-Carlo simulations. We will implement the new light sensor in an optical tomograph and achieve a 100x improvement of SNR compared to using existing light sensors. With our proposed Multifunctional Optical Tomograph we will be able to image deep organ and optical structures and monitor functions including oxygenation, haemodynamics, perfusion and metabolism

传统上，器官和深部功能成像的监测是通过超声波、X射线(包括CT)、PET或MRI来完成的。这些技术只允许非常有限的功能测量，通常与外源性和放射性试剂相结合。在这个项目中，我们提出了一种创新的光传感解决方案--快速门控、超高量子效率的单光子传感器，以实现具有漫反射光学的多功能深体成像。这种新型传感器基于超导纳米线单光子探测器，已被证明是超快和高效的。然而，到目前为止，活动区域和像素数一直限制在微米直径和数十个像素。我们提出了两种新的读出技术的组合，光学门控和电荷耦合，以克服这一限制，并扩展到10,000像素和毫米直径。此外，我们将开发新的策略来执行TD-NIRS和TD-SCOS，以通过蒙特卡罗模拟优化使用这种新的光传感器。我们将在光学断层扫描仪中实现新的光传感器，与使用现有的光传感器相比，信噪比将提高100倍。使用我们建议的多功能光学断层扫描仪，我们将能够对深层器官和光学结构进行成像，并监测包括氧合、血流动力学、灌注和新陈代谢在内的功能