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Development of reverse genetic systems and mouse model for SARS-CoV-2

Development of reverse genetic systems and mouse model for SARS-CoV-2
SARS-CoV-2反向遗传系统和小鼠模型的开发
批准号：
10398554
负责人：
Ricardo Rajsbaum
金额：
$19.75万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-05-01 至 2022-04-30
来源：
https://reporter.nih.gov/project-details/10398554
关键词：
2019-nCoVAnimal ModelAntiviral AgentsCOVID-19 pandemicCoronavirusDevelopmentGoalsModelingMusNatural ImmunityPathogenesisResearch PersonnelSystemVirus Replicationdisorder controlmouse modelmultidisciplinarypublic health emergencypublic health prioritiespublic health relevanceresponsereverse geneticstoolvaccine development

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ABSTRACT The recent epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global public health emergency. Rapid response to disease control and countermeasure development is a public health priority. Reverse genetic systems and animal models are essential tools for studying viral replication, pathogenesis, vaccine development, and antiviral discovery. The goals of this supplement project are to (i) establish the reverse genetic systems and (ii) generate a mouse pathogenesis model for SARS-CoV-2.
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