Development of reverse genetic systems and mouse model for SARS-CoV-2

SARS-CoV-2反向遗传系统和小鼠模型的开发

• 批准号: 10398554
• 负责人: Ricardo Rajsbaum
• 金额: $ 19.75万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398554
• 关键词: 2019-nCoV; Animal Model; Antiviral Agents; COVID-19 pandemic; Coronavirus; Development; Goals; Modeling; Mus; Natural Immunity; Pathogenesis; Research Personnel; System; Virus Replication; disorder control; mouse model; multidisciplinary; public health emergency; public health priorities; public health relevance; response; reverse genetics; tool; vaccine development

ABSTRACT The recent epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global public health emergency. Rapid response to disease control and countermeasure development is a public health priority. Reverse genetic systems and animal models are essential tools for studying viral replication, pathogenesis, vaccine development, and antiviral discovery. The goals of this supplement project are to (i) establish the reverse genetic systems and (ii) generate a mouse pathogenesis model for SARS-CoV-2.

摘要 最近流行的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)已导致全球 突发公共卫生事件。疾病控制快速反应和对策制定是一种公共卫生 优先考虑。反向遗传系统和动物模型是研究病毒复制的基本工具， 发病机制、疫苗开发和抗病毒药物的发现。这一补充项目的目标是：(I) 建立反向遗传系统；(Ii)建立SARS-CoV-2小鼠致病模型。