Training Program in Molecular Metabolism

分子代谢培训项目

• 批准号: 10398989
• 负责人: Sudha B Biddinger
• 金额: $ 19.52万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398989
• 关键词: Metabolism; Molecular; Training Programs

ABSTRACT The Molecular Metabolism Training Program (MMTP) at the Harvard Chan School of Public Health (HSPH) will train a new generation of academic scientists committed to conducting cutting-edge research in metabolism and metabolic disease. Central features of this program include integration of innovative platforms in ‘omics, microbiome analysis, animal physiology, imaging, and other technologies for analyzing metabolism; unique coursework in metabolism and metabolic disease, biostatistics, epidemiology, and computational analysis with a public health focus; and a collaborative faculty based at HSPH and adjacent institutions in the Longwood Medical Area. MMTP leverages the innovative training environment offered at a top public health institution, supplementing it with rigorous training in emerging molecular analysis tools. Trainees will study both individual and population aspects of disease and other unique resources offered at a school of public health. The vibrant community of twenty-one faculty mentors studies multidisciplinary questions such as the interactions between the immune system and exercise or over-nutrition; the effect of the microbiome on metabolism; the role of lipid drop or mitochondrial dynamics in metabolic homeostasis; or the effects of metabolic flux on energy metabolism in well and disease states. Research focuses on understanding the most significant challenges to global public health, including metabolic syndrome and the related lipotoxic diseases of type 2 diabetes, non-alcoholic fatty liver disease, metabolic diseases of an aging population, immunometabolism, and immune and microbiome contributions to digestive health. We are requesting funding for three new predoctoral students and one postdoctoral fellow every year, so the T32 would support twenty trainees over its five years. Pre-doctoral students will obtain a PhD in Biological Sciences in Public Health (BPH) from one of the most highly ranked public health doctoral programs in the nation. BPH attracts a diverse student body and has a successful track record in supporting these students. Postdoctoral fellows will have access to coursework, mentors, and a highly interactive metabolism research community. MMTP will thus train a diverse group of interdisciplinary scientists who can apply innovative research methods to understand fundamental questions in human metabolism.

摘要 哈佛陈医学院的分子代谢训练计划（MMTP） 公共卫生（HSPH）将培养新一代的学术科学家， 进行代谢和代谢疾病的前沿研究。这方面的主要特点 计划包括整合创新平台在'组学，微生物组分析，动物 生理学，成像和其他技术分析代谢;独特的课程， 代谢和代谢性疾病，生物统计学，流行病学和计算分析， 一个公共卫生的重点;和一个合作的教师在HSPH和邻近的机构在 朗伍德医疗区 MMTP利用在顶级公共卫生机构提供的创新培训环境， 机构，补充它与严格的培训，在新兴的分子分析工具。学员 将研究疾病的个人和人口方面以及提供的其他独特资源 在一所公共卫生学校由21名教师导师组成的充满活力的社区研究 多学科的问题，如免疫系统和运动之间的相互作用， 营养过剩;微生物组对代谢的影响;脂质下降或线粒体的作用 代谢动态平衡;或代谢通量对能量代谢的影响， 以及疾病状态。研究的重点是了解最重大的挑战， 全球公共卫生，包括代谢综合征和相关的2型脂毒性疾病 糖尿病、非酒精性脂肪肝、老龄化人群的代谢疾病， 免疫代谢以及免疫和微生物组对消化系统健康的贡献。 我们正在申请资助三名新的博士前学生和一名博士后 因此，T32将在五年内支持20名学员。博士前 学生将获得公共卫生生物科学博士学位（BPH）从最 在全国排名很高的公共卫生博士课程。BPH吸引了多元化的学生团体 并在支持这些学生方面有着成功的记录。博士后研究员将有 获得课程，导师和高度互动的代谢研究社区。 因此，MMTP将培养一批不同的跨学科科学家，他们可以应用创新技术， 研究方法，以了解人体代谢的基本问题。