Marriage, Cognitive Trajectories and ADRD Risk in Late Life

婚姻、认知轨迹和晚年 ADRD 风险

• 批准号: 10400187
• 负责人: Hui Liu
• 金额: $ 13.66万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2023-08-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400187
• 关键词: Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Behavioral; Biography; Biological Factors; Cognition; Cognitive; Cognitive aging; Complex; Conflict (Psychology); Data; Dementia; Diabetes Mellitus; Dimensions; Divorce; Economics; Elderly; Emotional; Epidemiology; Exposure to; Family; Foundations; Goals; Guidelines; Health; Health Care Costs; Health and Retirement Study; Health behavior; Impaired cognition; Income; Individual; Institution; Interdisciplinary Study; Intervention; Knowledge; Life; Life Cycle Stages; Link; Longevity; Marital Relationships; Marital Status; Marriage; Marriage and Family; Measures; Mediation; Methodology; Methods; Neurology; Neuropsychology; Never Married; Pathway interactions; Pattern; Personal Satisfaction; Policies; Population; Positioning Attribute; Prevention strategy; Process; Public Health; Recording of previous events; Research; Research Design; Risk; Risk Factors; Scientist; Smoking; Social Change; Social support; Statistical Methods; Stress; Talents; Testing; United States National Institutes of Health; Unmarried; Vulnerable Populations; Widowhood; base; biodemography; cognitive function; dementia risk; drinking; experience; gender difference; healthy lifestyle; innovation; insight; longitudinal dataset; population health; protective factors; psychologic; psychological distress; psychosocial; satisfaction; social; social determinants; social relationships; trait; treatment strategy; trend

Project Summary In the past decades, extensive research has aimed to identify risk factors, causative agent, treatments and preventive strategies for Alzheimer's disease (AD), the most common type of dementia. These efforts have predominantly focused on proximate behavioral and biological factors, but the upstream social determinants of cognitive decline and AD and related dementias (ADRD) are not well-understood. The overall objective of this proposed project is to ascertain how marriage, an important but overlooked social risk/protective factor, is linked to trajectories of cognitive decline and risk of developing dementia in late life. Marriage has long been identified as the most important type of social relationships that holds the greatest significance for health during adulthood. However, surprisingly, scientists know little about whether and how marriage influences cognitive decline and progression to ADRD. Rapid social changes in marriage, family formation, and family dissolution mean that an increasing number of older Americans are entering late life with complex marital histories, which reshapes key aspects of their lives, and may in turn affect cognitive function over the life course. We hypothesize that the complex life-course traits of marital relationships such as current marital status, histories of marital dissolutions, and marital strain, will influence trajectories of cognitive decline and dementia risk over one’s life course via multifaceted economic, psychosocial, behavioral, and biomedical pathways. This project breaks new ground with an innovative interdisciplinary life-course research design that conjoins data from three NIH-sponsored, national, longitudinal datasets: (1) Health and Retirement Study (HRS), (2) National Health and Aging Trends Study (NHATS), and (3) National Social Life, Health and Aging Project (NSHAP) to examine a full life course picture of marital relationships including marital status, marital biography and marital quality linked to cognitive trajectories and dementia. We will apply advanced statistical methods to systematically examine economic, psychosocial, behavioral and biomedical mechanisms through which marriage influences cognitive trajectories and dementia risk over the life course, and further assess potential gender differences in the processes. The interdisciplinary research team is characterized by a complementary set of talents and experience in population health, cognitive aging, marriage and social relationships, neurology, neuropsychology, bio-demography, epidemiology and quantitative methodologies that uniquely position them to carry out this innovative project.

项目摘要 在过去的几十年中，广泛的研究旨在确定风险因素，因果关系 阿尔茨海默氏病（AD）的特工，治疗和预防策略，最常见的 痴呆症的类型。这些努力主要集中于近端行为和 生物学因素，但上游的社会决定者认知能力下降，AD和相关 痴呆症（ADRD）并不理解。这个拟议项目的总体目标是 确定婚姻是一种重要但被忽视的社会风险/保护因素，与 认知能力下降和后期痴呆症的风险的轨迹。 婚姻长期以来一直被确定为最重要的社会关系类型 在成年期间对健康具有最大的意义。但是，令人惊讶的是科学家 了解以及婚姻是否以及如何影响认知能力下降和进步 adrd。婚姻，家庭形成和家庭解散的快速社会变化意味着 越来越多的年长的美国人正在以复杂的婚姻历史进入后期生活，这是 重塑其生活的关键方面，反过来可能会影响人生过程中的认知功能。 我们假设婚姻关系的复杂生活特征，例如当前 婚姻状况，婚姻解散的历史和婚姻压力将影响 通过多方面的经济，认知能力下降和痴呆症风险在一个人的生活过程中风险 社会心理，行为和生物医学途径。 该项目通过创新的跨学科生命研究破坏了新的基础 设计可以连接来自三个NIH赞助的国家，纵向数据集的数据：（1）健康 和退休研究（HRS），（2）国家健康和衰老趋势研究（NHAT）和（3） 国家社会生活，健康和衰老项目（NSHAP）检查完整的生活课程图片 婚姻关系，包括婚姻状况，婚姻传记和婚姻质量 认知轨迹和痴呆症。我们将应用高级统计方法 系统地检查经济，社会心理，行为和生物医学机制 婚姻会影响人生过程中的认知轨迹和痴呆症风险， 并进一步评估过程中潜在的性别差异。 跨学科研究团队的特征是一组完善的才能 以及人口健康，认知老化，婚姻和社会关系方面的经验， 神经学，神经心理学，生物人物学，流行病学和定量方法 这独特地将他们定位为执行这个创新的项目。