Enhancing neurogenesis in the adult primate brain

增强成年灵长类动物大脑的神经发生

• 批准号: DP150104168
• 负责人: Prof Cynthia Shannon Weickert
• 金额: $ 21.42万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104168
• 关键词: Enhancing; neurogenesis; adult; primate; brain

New neurons are robustly generated in the subependymal zone (SEZ) during human development. Thus, the SEZ may represent an endogenous modifiable source of neurons to enhance plasticity and therapeutic potential in the brain. However, despite our preliminary data, SEZ neurogenesis beyond the first months of life is controversial. This project aims to understand changes in the capacity for human SEZ proliferation from birth through to ageing and whether neurogenesis may be induced by inflammation in the adult. Using transcriptomics we will also determine how the neurogenic environment changes with age/inflammation. This project is an important step in proving that the brain's potential to generate new neurons extends beyond infancy.

在人类发育过程中，新的神经元在室管膜下区（SEZ）中大量产生。因此，经济特区可能代表神经元的内源性可修饰来源，以增强大脑的可塑性和治疗潜力。然而，尽管我们有初步数据，但生命最初几个月后经济特区的神经发生仍存在争议。该项目旨在了解人类经济特区从出生到衰老的增殖能力的变化，以及成人炎症是否可能诱导神经发生。使用转录组学，我们还将确定神经源性环境如何随着年龄/炎症而变化。该项目是证明大脑产生新神经元的潜力超越婴儿期的重要一步。