Enhancing neurogenesis in the adult primate brain

在人类发育过程中，新的神经元在室管膜下区（SEZ）中稳健地产生。因此，SEZ可能代表神经元的内源性可修饰来源，以增强大脑的可塑性和治疗潜力。然而，尽管我们的初步数据，经济特区神经发生超过生命的第一个月是有争议的。该项目旨在了解从出生到衰老的人类SEZ增殖能力的变化，以及成年后炎症是否会诱导神经发生。使用转录组学，我们还将确定神经源性环境如何随年龄/炎症而变化。这个项目是证明大脑产生新神经元的潜力超越婴儿期的重要一步。

New neurons are robustly generated in the subependymal zone (SEZ) during human development. Thus, the SEZ may represent an endogenous modifiable source of neurons to enhance plasticity and therapeutic potential in the brain. However, despite our preliminary data, SEZ neurogenesis beyond the first months of life is controversial. This project aims to understand changes in the capacity for human SEZ proliferation from birth through to ageing and whether neurogenesis may be induced by inflammation in the adult. Using transcriptomics we will also determine how the neurogenic environment changes with age/inflammation. This project is an important step in proving that the brain's potential to generate new neurons extends beyond infancy.