Context-based neural representations of space: hippocampal-entorhinal neurophysiology in ambulating humans

摘要： 记忆力减退伴随着许多神经和精神疾病。告知…的发展情况 有效的治疗，了解复杂的记忆是如何在海马体内嗅觉皮质中编码的 系统(HPC-ERC)至关重要。成功的情节记忆(个人事件)的形成需要 跨维度的信息集成，包括空间内体验的上下文 环境。拟议的研究计划将确定HPC-ERC系统如何灵活编码 使用人类罕见的侵入性神经记录，在不同的空间环境中进行记忆。 数据将从两组不同但互补的植入电极的参与者中收集：(1) 来自HPC-ERC的具有同时单单位/局部场势(LFP)记录的固定参与者 (2)使用慢性HPC-ERC iEEG记录电极的自由活动受试者。参赛者将表演 具有生态意义的3D沉浸式虚拟现实(VR)空间导航任务，在床边(1)或 在自由移动期间(2)。这些发现将说明构成以下表述的关键神经机制 自由移动的人类的空间和记忆，以及这些表征如何编码上下文的变化。 此外，这项提案将确定在人类中单一单位和LFP活动之间的关系 与空间导航和上下文变化的关系，使用3D VR。结果将促进我们对 空间导航、记忆和上下文更改的效果的HPC-ERC表示 这些都是开发治疗记忆障碍的神经疗法的科学基础。

ABSTRACT: Memory decline accompanies numerous neurological and psychiatric diseases. To inform the development of effective therapies, understanding how complex memories are encoded in the hippocampal-entorhinal cortex system (HPC-ERC) is critical. Formation of successful episodic memories (of personal events) requires the integration of information across dimensions including the context of an experience within a spatial environment. The proposed research program will determine how the HPC-ERC system flexibly encodes memories across different spatial environmental contexts using rare invasive neural recordings in humans. Data will be collected from two distinct but complementary groups of participants with implanted electrodes: (1) stationary participants with simultaneous single-unit/local field potential (LFP) recordings from the HPC-ERC and (2) freely moving participants with chronic HPC-ERC iEEG recording electrodes. Participants will perform an ecologically meaningful 3D immersive virtual reality (VR) spatial navigation task, either at the bedside (1) or during free movement (2). Findings will illustrate critical neural mechanisms that underlie representations of space and memory in freely moving humans and how these representations encode contextual changes. Additionally, this proposal will identify the relationship between single-unit and LFP activity in humans in relation to spatial navigation and contextual changes, using 3D VR. Results will advance our understanding of HPC-ERC representations of spatial navigation, memory, and the effect of contextual changes that will together serve as a scientific foundation for development of neurological therapies for disorders of memory.