Context-based neural representations of space: hippocampal-entorhinal neurophysiology in ambulating humans

摘要： 记忆力下降伴随着许多神经和精神疾病。从而有助于制定 有效的治疗方法，了解复杂的记忆是如何在大脑皮层中编码的 系统（HPC-ERC）至关重要。成功的情景记忆（个人事件）的形成需要 跨维度的信息整合，包括空间内的体验背景 环境拟议的研究计划将确定HPC-ERC系统如何灵活地编码 在人类中使用罕见的侵入性神经记录跨越不同空间环境背景的记忆。 将从植入电极的两组不同但互补的参与者中收集数据：（1） 静止受试者，同时记录HPC-ERC的单单位/局部场电位（LFP） （2）自由活动的受试者，使用慢性HPC-ERC iEEG记录电极。参赛者将表演 具有生态意义的3D沉浸式虚拟现实（VR）空间导航任务，无论是在床边（1）还是 自由活动（2）。研究结果将说明关键的神经机制，表示的基础 空间和记忆在自由移动的人，以及如何这些表征编码上下文的变化。 此外，该提案将确定人类中单个单位和LFP活性之间的关系， 与空间导航和上下文变化的关系，使用3D VR。研究结果将促进我们对 HPC-ERC表示空间导航，记忆和上下文变化的影响， 共同作为记忆障碍神经疗法发展的科学基础。

ABSTRACT: Memory decline accompanies numerous neurological and psychiatric diseases. To inform the development of effective therapies, understanding how complex memories are encoded in the hippocampal-entorhinal cortex system (HPC-ERC) is critical. Formation of successful episodic memories (of personal events) requires the integration of information across dimensions including the context of an experience within a spatial environment. The proposed research program will determine how the HPC-ERC system flexibly encodes memories across different spatial environmental contexts using rare invasive neural recordings in humans. Data will be collected from two distinct but complementary groups of participants with implanted electrodes: (1) stationary participants with simultaneous single-unit/local field potential (LFP) recordings from the HPC-ERC and (2) freely moving participants with chronic HPC-ERC iEEG recording electrodes. Participants will perform an ecologically meaningful 3D immersive virtual reality (VR) spatial navigation task, either at the bedside (1) or during free movement (2). Findings will illustrate critical neural mechanisms that underlie representations of space and memory in freely moving humans and how these representations encode contextual changes. Additionally, this proposal will identify the relationship between single-unit and LFP activity in humans in relation to spatial navigation and contextual changes, using 3D VR. Results will advance our understanding of HPC-ERC representations of spatial navigation, memory, and the effect of contextual changes that will together serve as a scientific foundation for development of neurological therapies for disorders of memory.