Clinical Core

项目摘要 拟建的狼疮研究中心将利用广泛的技术， 监测推动患者疾病活动的分子途径，以实现个性化治疗的最终目标， 治疗方法。这个项目的累积努力将产生一个宝贵的样本库， 为拟议的研究和未来的实验问题提供资源。因此，必要的和重要的 临床中心的使命是确保所有患者都能接受全面的临床评估， 患者样本和临床数据将被系统地编目和跟踪，充分储存， 适当传播。 该核心将来自UT西南部儿童健康儿科流变学部门 医疗中心（UTSW）和全国儿童医院在俄亥俄州大学（NCH），并利用 从特征良好的儿童SLE患者（在生命早期表现出疾病）中获得的样本的可用性， 呈现极端的表型并且缺乏混淆表型的共病。通过以下途径获得血液样本： 该临床部分将作为整个拟议中心的儿科患者样本来源， 狼疮研究。 临床核心将建立在现有的优势和扩展，以协调样本和数据采集， 处理，存储和分发此P50赠款提案。核心将利用长期存在的 帕斯夸尔博士和赖特之间的合作，并扩大合作博士Ardoin，以扩大 核心的能力和杰出的组织发展，以联络诊所和研究实验室。 这些策略和优势将使拟建狼疮研究中心的科学家们能够从不同的角度， 机构无缝合作，使研究人员能够跟踪相关的临床和实验室数据， 与样本，以确保科学合理的相关研究，并促进真正的协同计划。

Project Summary The proposed Center for Lupus Research will take advantage of a wide range of technologies that will be applied to monitor molecular pathways driving disease activity in patients toward the ultimate goal of a personalized approach to therapy. Cumulative efforts from this project will generate an invaluable sample repository as a resource both for the proposed studies and future experimental questions. Thus, the necessary and important mission of the Clinical Core is to ensure that all patients will have a comprehensive clinical assessment and that patient samples and clinical data will be systematically catalogued and tracked, adequately stored, and appropriately disseminated. This Core will arise from the Divisions of Pediatric Rheumatology at Children’s Health at UT Southwestern Medical Center (UTSW) and Nationwide Children’s Hospital at Ohio University (NCH) and take advantage of the availability of samples from well-characterized pediatric SLE patients, who manifest disease early in life, often present extreme phenotypes and lack co-morbidities that confound the phenotypes. Blood samples obtained via this Clinical Component will serve as the source of pediatric patient samples for the entire proposed Center for Lupus Research. The Clinical Core will build upon existing strengths and expand to coordinate sample and data acquisition, processing, storage, and distribution for this P50 grant proposal. The Core will capitalize on the long-standing collaboration between Drs. Pascual and Wright and extend the collaboration to Dr. Ardoin in order to expand the Core’s capabilities and the outstanding organization developed to liaise the clinic and the research laboratory. These strategies and strengths will enable scientists of the proposed Center for Lupus Research from different institutions to work together seamlessly and allow investigators to track clinical and laboratory data associated with samples to ensure scientifically sound correlative studies and facilitate a truly synergistic program.