Synthetic biology to engineer novel disease resistance in cereal crops

合成生物学设计谷类作物新的抗病性

• 批准号: DE210100323
• 负责人: Dr Xiaoxiao Zhang
• 金额: $ 32.34万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-11 至 2024-12-25
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE210100323
• 关键词: Synthetic; biology; engineer; novel; disease

This project aims to engineer disease resistance in crops to dangerous fungal pathogens. The strategy is to exploit our knowledge of the plant immune system using structural biology and directed evolution of natural resistance genes, improving their ability to recognise and respond to fungal attack. Fungal pathogens cause some of the most harmful crop diseases in Australia and worldwide. The rapid evolution of fungi overcomes natural plant resistance and management of these diseases is a major challenge to agriculture. Expected outcomes of the project include engineered wheat plants with more effective disease resistance, reducing fungicide usage. This project intends to accelerate crop breeding and contribute to world food security.

该项目旨在改造农作物对危险真菌病原体的抗病能力。我们的战略是利用我们对植物免疫系统的知识，利用结构生物学和定向进化自然抗性基因，提高它们识别和应对真菌攻击的能力。真菌病原体在澳大利亚和世界范围内造成了一些最有害的作物病害。真菌的快速进化克服了植物的天然抗性，对这些疾病的管理是农业的一大挑战。该项目的预期成果包括转基因小麦植株具有更有效的抗病能力，减少杀菌剂的使用。该项目旨在加快作物育种，为世界粮食安全做出贡献。