Supplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF Biomarkers
AMP-AD 脑蛋白质组网络的补充,增强、验证并转化为 CSF 生物标志物
基本信息
- 批准号:10406764
- 负责人:
- 金额:$ 29.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaArchivesBenchmarkingBiological MarkersBrainClassificationCognitionCustomDegenerative DisorderDevelopmentDiagnosisDocumentationEngineeringFoundationsFundingGoalsGrantImage AnalysisInformaticsMalignant NeoplasmsNeurodegenerative DisordersOnline SystemsParentsPathologyPhenotypeProteinsProteomicsQuantitative EvaluationsReadinessResearchResearch SupportSamplingScienceSideSlideStagingTissuesTranslationsUnited States National Institutes of HealthValidationVisualizationWorkbrain tissuecloud basedcomputing resourcesdiagnostic accuracydigitalimprovedinnovationneuropathologyopen sourceprecision medicineprotein biomarkerssharing platformtask analysistool
项目摘要
The goal of the parent AMP-AD project is to identify proteomic networks from cortical tissue and identify
protein co-expression modules that are strongly associated with diagnosis, cognition and neuropathology.
These studies hinge on accurate neuropathologic diagnosis and staging of the brain tissue. These
assessments typically involve semi-quantitative evaluation of tissues and there is a need for robust, reliable,
and scalable deeper phenotyping to provide a firmer foundation for precision medicine approaches. We have
developed the Digital Slide Archive (DSA) platform at Emory, which has been funded through a U24 and U01
grants from the NCI/NIH and has primarily been optimized for Cancer related image analysis workflows. In this
project, we propose to deploy and customize a web-based instance of our open source management and
visualization platform, the Digital Slide Archive (DSA). Ultimately, we will enable collaborative team science
and adapt the existing DSA platform for a neuropathologist’s workflow. This will directly enhance the value of
our proteomic work by allowing us to better annotate our brain/proteomic samples.
In this proposal, we propose enhancing the user interface of the DSA to better accommodate a
neuropathologist’s workflow for reviewing brain tissue, and develop an easily installable Neuropath plugin for
the DSA. We will also benchmark and optimize our analysis suite (HistomicsTK) on NP slide sides on local
and cloud-based computational resources, and prepare tutorials demonstrating how our tools can be used for
ADRD related image analysis tasks. These aims paired with the complementary and synergistic expertise of
our informatics, pathology, and engineering will aid in development of robust, scalable, reliable, and sharable
platforms to provide a foundation for innovative transformative science addressing a critical unmet need in
neurodegenerative disease research.
母体 AMP-AD 项目的目标是识别皮质组织中的蛋白质组网络并识别
与诊断、认知和神经病理学密切相关的蛋白质共表达模块。
这些研究取决于准确的神经病理学诊断和脑组织分期。这些
评估通常涉及组织的半定量评估,并且需要稳健、可靠、
以及可扩展的更深层次的表型分析,为精准医学方法提供更坚实的基础。我们有
在埃默里大学开发了数字幻灯片存档 (DSA) 平台,该平台由 U24 和 U01 资助
来自 NCI/NIH 的资助,主要针对癌症相关图像分析工作流程进行了优化。在这个
项目中,我们建议部署和定制一个基于 Web 的开源管理实例,
可视化平台,数字幻灯片存档 (DSA)。最终,我们将实现协作团队科学
并根据神经病理学家的工作流程调整现有的 DSA 平台。这将直接提升价值
我们的蛋白质组工作使我们能够更好地注释我们的大脑/蛋白质组样本。
在此提案中,我们建议增强 DSA 的用户界面,以更好地适应
神经病理学家检查脑组织的工作流程,并开发一个易于安装的 Neuropath 插件
DSA。我们还将在本地 NP 幻灯片侧对我们的分析套件 (HistomicsTK) 进行基准测试和优化
和基于云的计算资源,并准备教程来演示如何使用我们的工具
ADRD 相关图像分析任务。这些目标与互补和协同的专业知识相结合
我们的信息学、病理学和工程学将有助于开发强大的、可扩展的、可靠的和可共享的
平台为创新变革科学提供基础,解决未满足的关键需求
神经退行性疾病研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David Andrew Gutman其他文献
David Andrew Gutman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David Andrew Gutman', 18)}}的其他基金
Piloting a web-based neuropathology image resource for the ADRC community
为 ADRC 社区试点基于网络的神经病理学图像资源
- 批准号:
10594297 - 财政年份:2020
- 资助金额:
$ 29.52万 - 项目类别: