Emory Alzheimer's Disease Research Center

埃默里阿尔茨海默病研究中心

• 批准号: 10408022
• 负责人: Nelson K Steenland
• 金额: $ 33.21万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408022
• 关键词: Address; Alzheimer' s Disease; Alzheimer’s disease biomarker; Autopsy; Bioinformatics; Biological Markers; Biometry; Blood Vessels; Clinical; Clinical Data; Clinical Research; Collaborations; Consult; Custom; DNA Methylation; Data; Data Collection; Data Mart; Data Storage and Retrieval; Databases; Development; Disease; Disease Progression; Early Diagnosis; Education; Ensure; Epidemiology; Equipment and supply inventories; Etiology; Faculty; Funding; Gene Expression; Genetic; Genomics; Goals; Grant; Grant Review; Human Resources; Image; Information Systems; Infrastructure; International; Laboratories; Link; Management Information Systems; Medicine; Methodology; Methods; Mission; Molecular; Monitor; Multiomic Data; Online Systems; Onset of illness; Peer Review; Prevention; Proteomics; Public Health Schools; Publications; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Sampling; Specimen; Statistical Methods; System; Systems Biology; Time; Tissues; Universities; Work; analytical method; base; computerized tools; data infrastructure; data integration; data integrity; data management; data repository; design; education research; epigenomics; gene discovery; imaging genetics; improved; innovation; large datasets; methylation biomarker; multimodality; neuroimaging; neuropathology; novel; novel marker; repository; statistics; transmission process

SUMMARY/ABSTRACT: DATA MANAGEMENT AND STATISTICS CORE The Data Management and Statistical (DMS) Core of the Emory Goizueta Alzheimer’s Disease Research Center (ADRC) supports studies on the causes, progression, and treatment of Alzheimer’s disease and related disorders (ADRD). The DMS Core accomplishes these goals by merging the data collection efforts of the Administrative, Clinical, Education, and Neuropathology Cores into a common repository, monitoring the integrity of these data, and transmitting the information in a timely fashion to investigators at the local, national, and international levels and to the National Alzheimer’s Coordinating Center. The DMS Core also lends their expertise on research design and analytic approaches to investigators, collaborates on and initiates ADRC- related studies, and develops innovative statistical approaches and methodologies. During the current funding period, the Emory DMS Core has invested heavily in its infrastructure to create an integrated, dynamic and accessible data solution, including deployment of web-based systems to improve data tracking, integration, and resource sharing. The DMS Core has engaged in increased collaborations on grants and peer-reviewed publications, and has developed new innovative methods to integrate multi-omics data and quantify postmortem tissue. In the next funding cycle, the DMS Core will achieve the following aims: (1) To continue to maintain a scientifically rigorous research database that supports NACC, the ADRC Cores, developmental projects, local investigator-initiated studies, Research Education Component trainees, and national collaborative studies; (2) To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation of ADRC related studies and grants; and (3) To develop innovative methods to support biomarker research on AD and ADRD, with a special emphasis on methods for multi-modal integration of genetics, proteomics, imaging, together with the clinical data. Through these efforts, leveraging and enhancing data infrastructure created over the last funding period, and integrating the diverse expertise of Core investigators, the DMS Core will facilitate cutting edge research to advance the field of AD and ADRD.

总结/摘要：数据管理和统计核心 Emory Goizueta阿尔茨海默病研究的数据管理和统计（DMS）核心 中心（ADRC）支持对阿尔茨海默病及其相关疾病的病因、进展和治疗的研究。 疾病（ADRD）。DMS核心通过合并 将管理、临床、教育和神经病理学核心整合到一个公共存储库中， 这些数据的完整性，并及时将信息传输给当地，国家， 以及国家阿尔茨海默氏症协调中心。DMS核心还提供 在研究设计和分析方法的专业知识，调查，合作，并启动ADRC- 我们还开展了相关研究，并制定了创新的统计办法和方法。在目前的资金 在此期间，埃默里DMS核心在其基础设施上投入了大量资金，以创建一个集成的，动态的， 无障碍数据解决方案，包括部署网络系统，以改进数据跟踪、整合 和资源共享。DMS核心参与了更多的赠款和同行评审合作， 出版物，并开发了新的创新方法来整合多组学数据和量化 死后组织 在下一个资助周期，DMS核心计划将达致以下目的：（1）继续维持 科学严谨的研究数据库，支持NACC，ADRC核心，发展项目，当地 教师发起的研究、研究教育部分的受训人员和国家合作研究;（2） 就ADRC的设计、执行、分析和解释提供统计咨询和协作 （3）发展创新方法，以支持阿尔茨海默病的生物标志物研究， ADRD，特别强调遗传学，蛋白质组学，成像， 以及临床数据。通过这些努力， 在最后一个资助期内，并整合核心调查人员的各种专业知识，DMS核心将 促进尖端研究，以推进AD和ADRD领域。