Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity

小胶质细胞是大脑的免疫细胞，已知能对神经系统的感染性和非感染性侮辱做出反应。该项目旨在利用斑马鱼透明和遗传上可服从的大脑，通过可视化大脑的细胞组件(神经元、胶质细胞、小胶质细胞、血管、突触)，并通过对突触密度的遗传操作，以及在此过程中对小胶质细胞的实时观察，在单个细胞水平上探索斑马鱼小胶质细胞的新功能。

Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. This project aims to use the transparent and genetically amenable brain of the zebrafish, to explore new functions of microglia at the single cell level in the intact, behaving animal, through visualization of cellular components of the brain (neurons, glia, microglia, blood vessels, synapses), and through the genetic manipulation of synaptic density, and real time observation of microglia in the process.