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Non-Contrast DWI for Supplemental Screening of Women with Dense Breasts

非对比 DWI 对致密乳房女性的补充筛查

基本信息

批准号：
10415912
负责人：
Savannah Corrina Partridge
金额：
$ 33.91万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10415912
关键词：
Address American American Cancer Society Assessment tool Awareness Benign Biopsy Brain Breast Breast Cancer Detection Breast Cancer Risk Factor Breast Magnetic Resonance Imaging Cancer Detection Cancer Etiology Cessation of life Clinical Complement Computer Assisted Consensus Contrast Media DNA Sequence Alteration Data Deposition Detection Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Echo-Planar Imaging Environment Exhibits Family Gadolinium Guidelines Health Image Analysis Imaging Techniques Intravenous Lesion Magnetic Resonance Imaging Malignant - descriptor Malignant Neoplasms Mammary Gland Parenchyma Mammary Ultrasonography Mammographic screening Mammography Methods Microscopic Noise Outcome Outcome Study Performance Population Provider Public Health ROC Curve Reader Recording of previous events Research Resolution Risk Role Scanning Screening for cancer Screening procedure Sensitivity and Specificity Standardization Statutes and Laws Techniques Testing Time Toxic effect Woman Women&apos s Health base breast density clinical implementation contrast enhanced cost design imaging approach improved lifetime risk malignant breast neoplasm novel patient safety performance tests screening supplemental screening tool ultrasound

项目摘要

Abstract Breast cancer is extremely common, striking 1 in 8 American women, and is the second leading cause of cancer death among women in the U.S. Women with dense breasts on screening mammography have a two to five times increased risk of developing breast cancer, and increased breast density reduces the sensitivity of mammography for cancer detection. As a result, a growing number of states have passed legislation mandating that women have a right to know if their breast density is increased. Unfortunately, there are no clear guidelines as to what women should do with this information or appropriate supplemental screening strategies. Studies investigating the use of ultrasound in this role have not been convincing, generally showing low added cancer yield and high rate of false positives. On the other hand, contrast-enhanced MRI has the highest sensitivity for detecting cancers in dense breasts, but barriers to more widespread use of breast MRI include high costs, relatively lengthy scanning times, and contraindications related to administration of gadolinium-based contrast. Furthermore, new research providing evidence of accumulation of gadolinium- based contrast agents in the brain has raised awareness and concerns about the risk of long-term use of contrast-enhanced MRI for screening and surveillance. An effective, low cost, safe screening method is needed to detect mammographically occult cancers in women with dense breasts. Diffusion-weighted imaging (DWI) is a short (2-3 minutes) non-contrast MRI technique that has shown promise for the detection and characterization of breast cancer. Our preliminary data has shown that DWI holds potential for detecting mammographically and clinically-occult breast cancers. However, current technical limitations reduce the sensitivity of DWI for screening applications. We hypothesize that an optimized DWI approach will enable detection of mammographically occult breast cancer in women with dense breasts with high sensitivity and low false positive rate. Aims of the study will be to 1) optimize the DWI acquisition 2) develop an interpretation strategy and tools, and 3) test the performance of DWI for detecting mammographically-occult breast cancer in women with dense breasts. If successful, non-contrast DWI could provide a viable supplemental screening tool to improve early detection of cancer in women with dense breasts.

摘要

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Visibility of mammographically occult breast cancer on diffusion-weighted MRI versus ultrasound.

DOI：
10.1016/j.clinimag.2017.10.017
发表时间：
2018-05
期刊：
Clinical imaging
影响因子：
2.1
作者：
Amornsiripanitch N;Rahbar H;Kitsch AE;Lam DL;Weitzel B;Partridge SC
通讯作者：
Partridge SC

Editorial for "Contrasts Between Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MR in Diagnosing Malignancies of Breast Nonmass Enhancement Lesions Based on Morphologic Assessment".

“基于形态学评估的弥散加权成像与动态对比增强 MR 诊断乳腺非肿块增强病变恶性肿瘤的对比”的社论。

DOI：
10.1002/jmri.28620
发表时间：
2023
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
0
作者：
Partridge,SavannahC;Kazerouni,AnumS
通讯作者：
Kazerouni,AnumS

Imaging for Response Assessment in Cancer Clinical Trials.

DOI：
10.1053/j.semnuclmed.2020.05.001
发表时间：
2020-11
期刊：
Seminars in nuclear medicine
影响因子：
4.9
作者：
Sorace AG;Elkassem AA;Galgano SJ;Lapi SE;Larimer BM;Partridge SC;Quarles CC;Reeves K;Napier TS;Song PN;Yankeelov TE;Woodard S;Smith AD
通讯作者：
Smith AD

DWI in the Assessment of Breast Lesions.

DOI：
10.1097/rmr.0000000000000137
发表时间：
2017-10
期刊：
Topics in magnetic resonance imaging : TMRI
影响因子：
0
作者：
Partridge SC;Amornsiripanitch N
通讯作者：
Amornsiripanitch N

Impact of Alternate b-Value Combinations and Metrics on the Predictive Performance and Repeatability of Diffusion-Weighted MRI in Breast Cancer Treatment: Results from the ECOG-ACRIN A6698 Trial.

DOI：
10.3390/tomography8020058
发表时间：
2022-03-04
期刊：
Tomography (Ann Arbor, Mich.)
影响因子：
0
作者：
Partridge SC;Steingrimsson J;Newitt DC;Gibbs JE;Marques HS;Bolan PJ;Boss MA;Chenevert TL;Rosen MA;Hylton NM
通讯作者：
Hylton NM