Clinical Research Resources and Facilities

临床研究资源和设施

• 批准号: 10417259
• 负责人: MELVIN BONILLA-FELIX
• 金额: $ 23.97万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-02 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10417259
• 关键词: Address; Adherence; Cardiometabolic Disease; Caribbean Hispanic; Clinical Practice Guideline; Clinical Research; Communicable Diseases; Communities; Core Facility; Data; Development; Disasters; Disease; Emerging Communicable Diseases; Ensure; Goals; Good Clinical Practice; Health; Healthcare; Hispanic; Hispanic Populations; Hispanic-serving Institution; Infrastructure; Interdisciplinary Study; Knowledge; Language; Malignant Neoplasms; Methodology; Minority; Participant; Population; Positioning Attribute; Process; Puerto Rico; Regulation; Research; Research Personnel; Resources; Scientist; Structure; Subgroup; Translating; Translational Research; burden of illness; cost effective; cultural competence; effective therapy; ethnic minority; hispanic community; human subject; improved; medically underserved; medically underserved population; programs; quality assurance; racial minority; recruit; research facility; research study; retention rate; treatment guidelines

Abstract/Summary Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. Limited representation of racial and ethnic minorities in clinical and translational research is an important challenge that limits the generalizability of results and contributes to the disproportionate disease burden in these groups. There is a need to increase the representation of Hispanic research participants and researchers in clinical and translational research to improve the generalizability and applicability of research findings and identify ethnic-specific differences that could dictate changes in treatment guidelines and facilitate research in this population. The Clinical Research Resources and Facilities Core of the Alliance is well positioned to address the gap in the participation of Hispanic subjects in clinical research and increase the number of Hispanic scientists participating in clinical and translational research, given their access to resident populations of both underrepresented Hispanic participants and Hispanic scientists. The goal of the Clinical Research Resources and Facilities Core (CRRF) is to facilitate and enhance safe and cost-effective clinical and translational research, with an emphasis in health problems of Hispanics and medically underserved populations. The specific objective is to provide a coordinated structure across a predominantly Hispanic IDeA jurisdiction to support collaborative multi-and interdisciplinary clinical and translational research and increase the participation and retention of Hispanic research participants. The rationale that underlies this proposal is that establishing and integrating resources across multiple Hispanic-serving Institutions and groups, staffed by culturally consonant investigators and staff, in a Hispanic US jurisdiction, will overcome many of the barriers that impact participation of Hispanics in research, which in turn will translate into more studies and more data about diseases prevalent in Hispanics. Our objective will be accomplished through three specific aims: 1) Establish an integrated network of clinical and translational research resources and facilities to enhance cost-effective, multidisciplinary and inter- disciplinary research, in health conditions prevalent among Hispanic populations; 2) Facilitate and increase the recruitment and retention of research participants from underserved Hispanic communities; 3) Ensure that clinical and translational research with human subjects is safe and of the highest quality. When these aims are completed we will impact the representation of Caribbean Hispanics as study participants and as investigators.

摘要/概要 改善医疗服务不足的人的医疗保健，包括我们的西班牙裔人口， 癌症、心脏代谢病和传染病等流行病仍然是一个重大挑战。 少数种族和少数民族在临床和转化研究中的有限代表性是一个重要的问题， 这一挑战限制了结果的普遍性，并导致这些国家的疾病负担不成比例， 组有必要增加西班牙裔研究参与者和研究人员的代表， 临床和转化研究，以提高研究结果的普遍性和适用性， 确定可能决定治疗指南变化的种族特异性差异，并促进 这个人口。联盟的临床研究资源和设施核心能够很好地解决 西班牙裔受试者参与临床研究的差距，并增加西班牙裔受试者的数量 参与临床和转化研究的科学家，考虑到他们可以接触到这两个地区的居民 西班牙裔参与者和西班牙裔科学家人数不足。临床研究资源的目标 和设施核心（CRRF）是促进和加强安全和具有成本效益的临床和翻译 研究，重点是西班牙裔和医疗服务不足的人群的健康问题。具体 目标是在以西班牙裔为主的IDEA司法管辖区提供协调结构，以支持 合作的多学科和跨学科的临床和转化研究，并增加参与和 保留西班牙裔研究参与者。这一建议的基本理由是， 整合跨多个西班牙裔服务机构和团体的资源，由文化和谐的工作人员 调查人员和工作人员，在西班牙裔美国司法管辖区，将克服许多影响参与的障碍， 西班牙裔的研究，这反过来将转化为更多的研究和更多的数据， 在西班牙裔。我们的目标将通过三个具体目标来实现：1）建立一个综合网络 临床和转化研究资源和设施，以提高成本效益，多学科和跨 学科研究，在西班牙裔人口中流行的健康状况; 2）促进和增加 招募和保留来自服务不足的西班牙裔社区的研究参与者; 3）确保 人类受试者的临床和转化研究是安全和最高质量的。当这些目标 完成后，我们将影响加勒比西班牙裔作为研究参与者和研究者的代表性。