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Imaging bacterial infections with 2nd generation maltodextrins

使用第二代麦芽糊精对细菌感染进行成像

基本信息

批准号：
10417147
负责人：
Mark Myron Goodman
金额：
$ 66.77万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10417147
关键词：
Abscess Acetals Animal Model Bacteria Bacterial Endocarditis Bacterial Infections Bacterial Model Chemical Structure Clinical Contrast Media Detection Diagnosis Early Diagnosis Endocarditis Environment Escherichia coli Evaluation Exhibits Family Generations Genus staphylococcus Gram-Negative Bacteria Gram-Negative Bacterial Infections Gram-Positive Bacteria Gram-Positive Bacterial Infections Health Healthcare Heart Valves Human Hydrolysis Image Imaging Techniques Imaging technology Implant In Vitro Infection Judgment Kinetics Label Lead Leukocytes Libraries Ligands Magnetic Resonance Imaging Mammalian Cell Metabolic Modeling Modification Morbidity - disease rate Osteomyelitis Positioning Attribute Positron-Emission Tomography Pre-Clinical Model Property Protocols documentation Pseudomonas aeruginosa Radiolabeled Rattus Resistance Scanning Sensitivity and Specificity Serum Specificity Staphylococcus aureus Streptococcus Structure Testing Translations Trioses base bone bone imaging clinically relevant cost experimental study imaging agent imaging probe in vivo maltodextrin mortality next generation novel scaffold targeted agent uptake

项目摘要

Bacterial infections ranging from heart valve infections (endocarditis) to bone infections (osteomyelitis) are a growing problem in health care today and cause significant morbidity and mortality. The unmet clinical need is our inability to diagnose bacterial infections at an early stage in a specific and sensitive manner. At present, heart valve infections, bone infections and abscesses are diagnosed on the basis of clinical judgment augmented by several non-specific imaging techniques (e.g., CT, MRI, white blood cell scans) and cultures. . However, these approaches are either indirect in the case of imaging or take several days in the case of cultures. The central objective of this proposal is to develop the next generation of maltodextrin based PET contrast agents that can image and diagnose early stage gram positive and gram negative infections. We have recently demonstrated that a new optimized maltodextrin targeting ligand termed thiomalto-triose that can image gram positive bacterial infections in vivo. The following specific aims are proposed: Specific Aim 1: Synthesis and Characterization of 18F thiomalto-triose based bacterial targeting ligands Specific Aim 2: Evaluation of lead compounds for the detection of gram negative infections in an animal model of bacterial osteomyelitis. Specific Aim 3: Evaluation of lead compounds for the detection of gram positive infections in an animal model of bacterial endocarditis

从心脏瓣膜感染（心内膜炎）到骨感染（骨髓炎）的细菌感染都是一种疾病