Clinical Core
临床核心
基本信息
- 批准号:10419277
- 负责人:
- 金额:$ 30.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-07 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AblationAddressAdherenceAdjuvantAdultAfricaAlgorithmsAllergic DiseaseAllergic ReactionAntibioticsAntigensAspirate substanceAutomobile DrivingAwardB-LymphocytesBioinformaticsBiological AssayBiological MarkersBloodBone MarrowCOVID-19 vaccineCatalogingCellsClinicalClinical ImmunologyClinical InvestigatorClinical ResearchClinical TrialsCollaborationsCommunicationComputer ModelsCytometryDataData AnalysesData SecurityData Storage and RetrievalDatabasesDevelopmentEnsureExposure toFine needle aspiration biopsyGoalsGood Clinical PracticeGuidelinesHospitalsHumanHuman ResourcesImmuneImmune responseImmunityImmunologic MonitoringImmunologyIndividualInfluenzaInformaticsInfrastructureInstitutional Review BoardsInvestigationLongitudinal StudiesMeasuresMessenger RNAMolecular ProfilingMonitorNational Institute of Allergy and Infectious DiseaseNatural ImmunityNaturePerformancePfizer-BioNTech COVID-19 vaccinePlasmaPopulationPractice GuidelinesPredispositionProceduresProcessProtocols documentationQuality ControlRNA vaccineRabiesRecombinantsReportingResearchResearch PersonnelResearch Project GrantsRoleSamplingSaponinsServicesSouth AfricanSpecial PopulationSpecimenStandardizationSystemT cell responseT-cell receptor repertoireTechnologyTimeTrainingTranslational ResearchUnited States National Institutes of HealthUpdateVaccinationVaccinesValidationWorkadaptive immunityantigen-specific T cellsbasebiological systemscytokinedata integrationdata managementdata submissionepigenomicsexpectationhuman subjecthuman subject protectionimprovedinfluenza virus vaccinemetabolomicsmicrobiomemicrobiotamultiple omicsnew technologynovelpublic databaserecruitresponsesample collectionsearch engineseasonal influenzasingle cell analysistranscriptomicsvaccine developmentvaccinology
项目摘要
1 ABSTRACT – Clinical Core
2 The Clinical Core of the Stanford HIPC U19 will provide state-of-the-art clinical and biospecimen support for all
3 the research projects, the Immune Monitoring and the Data Management and Analysis Cores, as well as the
4 expertise, facilities, personnel, procedures and processes for the implementation and conduct of the proposed
5 clinical projects. The Clinical Core will provide and update processes and training for clinical investigators and
6 staff; organize, implement, monitor and work to improve clinical project performance; and conduct quality control
7 and corrective action and handle protocol deviations (if needed), including assuring adherence to milestones,
8 project performance expectations, standardized approach in the recruitment and clinical characterization,
9 appropriate human subject protection measures and clinical Good Practice Guidelines. The Clinical Core will
10 provide the clinical research units which include the infrastructure for longitudinal studies: recruitment, retention,
11 data entry and data management, quality review, sample collection (blood, fine needle aspiration (FNA) and
12 bone marrow (BM) aspirates) processing, isolation and cataloging of various specimen types and will oversee
13 all regulatory-related documents and IRB compliant research. The Clinical Core will coordinate clinical
14 biospecimen storage informatics, connecting clinical, biospecimen management, and assay pipelines into a
15 cutting-edge search engine and analysis platform for clinical and translational research. The Clinical Core will
16 be led by Dr. Kari Nadeau with Associate Director Dr. Nadine Rouphael, Dr. Long at UCSF, and Drs. Madhi and
17 Nunez at hospitals in S. Africa. The Clinical Core will work closely with the other cores and projects to enable
18 the functional analysis of any samples with cutting-edge technologies. Drs. Nadeau, Rouphael, Long, Madhi,
19 and Nunez and their teams have the expertise to be able to comprehensively serve as the Clinical Core
20 personnel since they have been successful in other NIH related consortium studies, in performing Clinical Core
21 duties for other immunology clinical studies, and have worked with Drs. Pulendran, Davis, Maecker, Khatri and
22 Boyd for over 15 years. The Core Leader will represent the HIPC center in a HIPC Clinical Sub-Committee that
23 will operate under the HIPC Coordinating Center to promote cross-HIPC collaboration including sharing SOPs,
24 documents, and samples as appropriate. The Clinical Core proposes the following aims: (1) To perform clinical
25 studies with COVID-19 vaccines, and on the impact of the microbiome on rabies vaccination, to provide clinical
26 data and samples to accomplish the scientific goals of the research projects; (2) Establish and maintain
27 personnel training, procedures, and processes to provide core clinical support; and (3) Establish and maintain
28 protocol milestones, performance guidelines, communication strategies, and compliance in clinical studies and
29 sample collection. In summary, the Clinical Core will leverage state-of-the-art biospecimen support services and
30 will coordinate all operational and regulatory aspects of research for the HIPC U19 projects.
31
摘要:临床核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kari C. Nadeau其他文献
Baseline epitope-specific IgE profiles are predictive of sustained unresponsiveness or high threshold 1-year post oral immunotherapy in the POISED trial
在“口服免疫治疗疗效和安全性评估(POISED)”试验中,基线表位特异性免疫球蛋白E(IgE)谱可预测口服免疫治疗1年后持续无反应或高阈值反应情况。
- DOI:
10.1016/j.jaci.2024.10.017 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:11.200
- 作者:
Maria Suprun;Ashley Sang Eun Lee;Robert Getts;Simon Peck;Sayantani B. Sindher;Kari C. Nadeau;R. Sharon Chinthrajah;Stephen J. Galli;Hugh A. Sampson - 通讯作者:
Hugh A. Sampson
Identification , Characterization , and initial epitope mapping of a pine nut allergen
松子过敏原的鉴定、表征和初始表位作图
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Yuzhu Zhang;Wen;Yuting Fan;Jiang Yi;S. Lyu;Kari C. Nadeau;Tara H. McHugh - 通讯作者:
Tara H. McHugh
Novel dosing strategy of omalizumab during multi-allergen oral-immunotherapy
- DOI:
10.1016/j.waojou.2020.100415 - 发表时间:
2020-08-01 - 期刊:
- 影响因子:
- 作者:
Sayantani B. Sindher;Andrew Long;Natasha Purington;Divya Kumar;Stacey Skura;Margaret A. Woch;Tiffany Tan;Andres Alvarez;R. Sharon Chinthrajah;Maria Garcia-Lloret;Kari C. Nadeau - 通讯作者:
Kari C. Nadeau
How does global warming contribute to disorders originating from an impaired epithelial barrier?
全球变暖如何导致源自上皮屏障受损的疾病?
- DOI:
10.1016/j.anai.2023.08.010 - 发表时间:
2023-12-01 - 期刊:
- 影响因子:4.700
- 作者:
Cevdet Ozdemir;Umut Can Kucuksezer;Ismail Ogulur;Yagiz Pat;Duygu Yazici;Ioana Agache;Marek Jutel;Kari C. Nadeau;Mübeccel Akdis;Cezmi A. Akdis - 通讯作者:
Cezmi A. Akdis
Decreased Migratory Potential of Treg Cells in CRSwNP
- DOI:
10.1016/j.otohns.2010.06.707 - 发表时间:
2010-08-01 - 期刊:
- 影响因子:
- 作者:
Amanda Munoz;Kari C. Nadeau;Peter H. Hwang - 通讯作者:
Peter H. Hwang
Kari C. Nadeau的其他文献
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{{ truncateString('Kari C. Nadeau', 18)}}的其他基金
Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)
空气污染扰乱心肺总体健康中的炎症小体调节 (AIRHEALTH)
- 批准号:
10460326 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
空气污染的管理核心扰乱心肺总体健康(AIRHEALTH)研究中的炎症小体调节
- 批准号:
10269331 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
空气污染的管理核心扰乱心肺总体健康(AIRHEALTH)研究中的炎症小体调节
- 批准号:
10684157 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)
空气污染扰乱心肺总体健康中的炎症小体调节 (AIRHEALTH)
- 批准号:
10684155 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
Interaction between genetic, lifestyle and environmental factors determining circulating angiotensin-converting enzyme 2 protein expression: implications for the severity of COVID-19 infection
遗传、生活方式和环境因素之间的相互作用决定循环血管紧张素转换酶 2 蛋白表达:对 COVID-19 感染严重程度的影响
- 批准号:
10228516 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
Project 1 for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
空气污染扰乱心肺总体健康 (AIRHEALTH) 研究中的炎症小体调节项目 1
- 批准号:
10684167 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
Project 1 for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
空气污染扰乱心肺总体健康 (AIRHEALTH) 研究中的炎症小体调节项目 1
- 批准号:
10269334 - 财政年份:2021
- 资助金额:
$ 30.97万 - 项目类别:
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