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Active Help, Immune Function and Health Outcomes in Alzheimer's Caregivers

阿尔茨海默病护理人员的积极帮助、免疫功能和健康结果

基本信息

批准号：
10427209
负责人：
STEPHANIE L BROWN
金额：
$ 77.93万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10427209
关键词：
Address Alzheimer&apos s Disease Alzheimer&apos s disease caregiver Alzheimer&apos s disease related dementia Anti-Inflammatory Agents Anxiety Biological Markers Buffers Caregivers Caring Compassion Consensus Couples Data Dementia caregivers Distress Ecological momentary assessment Emotional Evaluation Family Caregiver Family member Goals Grief reaction Health Health Status Hormonal Hormones Hydrocortisone Immune system Individual Inflammation Investigation Literature Long Island Longitudinal Studies Measurement Measures Mediator of activation protein Mental Depression Mental Health Methodology Methods Modeling Morbidity - disease rate Motivation Neurobiology Neuropeptides Outcome Patient Self-Report Perception Personal Satisfaction Persons Population Progesterone Psychosocial Influences Questionnaires Regulation Research Risk Self Administration Stress Surveys TNF gene Testing Transforming Growth Factor beta United States National Institutes of Health Work care recipients caregiver interventions caregiver stress caregiving cytokine dementia caregiving design effective intervention experience follow-up health related quality of life immune function immune health immune system function improved informal caregiver informal caregiving mortality neurobehavioral perceived stress physical conditioning population based positive emotional state psychosocial receptor recruit repaired response vigilance

项目摘要

This proposal uses ecological momentary assessment (EMA) methods to examine how the provision of active help to individuals with Alzheimer’s Disease and related dementias (ADRD) influences the immune system and health of ADRD caregivers. We hypothesize that caregivers who feel emotionally close to the care recipient will show improvements in immune system biomarkers, self-reported health outcomes, and health-related quality of life as their active help increases. Two hundred and fifty caregivers will be recruited from the Center of Excellence for Alzheimer’s Disease of Long Island to participate in a three-wave longitudinal study in which we will collect data at baseline, 6 months, and 12 months. We will use EMA methods to collect data on active help and the caregiving context at baseline and 6 months, and and we will assess immune system activity and self-reported health outcomes at baseline, 6 months, and 12 months. Our analyses will test whether active help is beneficially associated with makers of inflammation (e.g., Il-6/TnF alpha-receptor) and repair (e.g., SOD, progesterone) among caregivers who feel emotionally close to the recipient.

本提案采用生态瞬时评估（EMA）方法，如何提供积极的帮助，以个人与阿尔茨海默氏症和相关的痴呆症（ADRD）影响ADRD照顾者的免疫系统和健康。我们假设，那些在情感上与被照顾者亲近的照顾者，显示免疫系统生物标志物的改善，自我报告的健康结果，和健康相关的生活质量，因为他们的积极帮助增加。二百将从老年痴呆症卓越中心招募50名护理人员，长岛疾病参与三波纵向研究，我们将在基线、6个月和12个月时收集数据。我们将使用EMA方法来在基线和6个月时收集关于主动帮助和康复背景的数据，以及我们将评估免疫系统活动和自我报告的健康结果，基线、6个月和12个月。我们的分析将测试主动帮助是否有益地与炎症标志物相关（例如，IL-6/TnF α受体）并且修复（例如，SOD，孕酮）在情感上亲近的照顾者中接受者