CORE A: Participant Measures and Assessments

CORE A.参与者的衡量标准和评估 总结/摘要 在ASPREE研究过程中，大量的临床、身体功能、认知和生活质量 由经过培训的工作人员从19，114名参与者中收集了数据（约2600万个数据值）， 参与者保留率（82%在研究结束时完全参与）、依从性（总体74%）和数据 质量（99.6%的准确率）。这一核心将建立在ASPREE业务成功的基础上， 通过协调、指导和管理所有与参与者有关的研究活动， ASPREE-XT中常规进行的生理和神经心理学评估和问卷调查 美国和澳大利亚的参与者。核心服务将确保质量，准确性和彻底性， 通过执行全面的标准作业程序从参与者收集数据 （SOP）并确保遵守SOP，在研究开始前，将对两个国家的工作人员进行培训 活动（参见Admin Core）。通过核心A活动提供的数据是所有项目的临床联系， 因为核心A将向核心B提供临床终点触发因素以进行随访。提供的纵向表型数据 核心A关于ASPREE-XT参与者的信息也将对实现本项目的总体目标至关重要。 U19通过完成项目分析。具体来说，收集与癌症有关的信息 筛查、癌症发病率、进展和结果对于项目1（癌症）至关重要。收集 认知数据、抑郁和痴呆终点对于评估痴呆和轻度认知障碍至关重要。 项目2（痴呆症）的损害结果。基本的日常生活活动、身体功能、疲惫和 将收集身体活动数据，用于项目3（残疾）的残疾和虚弱评估。 因此，U19的成功取决于将作为该核心的一部分收集的数据。 0

CORE A. PARTICIPANT MEASURES AND ASSESSMENTS SUMMARY/ABSTRACT During the course of the ASPREE study, a vast amount of clinical, physical function, cognitive and quality of life data (~26 million data values) were collected from 19,114 participants by trained staff, resulting in excellent participant retention (82% with full involvement at the end of the study), compliance (74% overall) and data quality (99.6% accuracy). This Core will build on the operational success of ASPREE and provide methodological and operational support for all participant-related study activity by coordinating, directing and managing the physiological and neuropsychological assessments and questionnaires conducted routinely in ASPREE-XT participants in both the U.S. and Australia. The Core services will ensure quality, accuracy and thoroughness of data collection from participants through the implementation of comprehensive Standard Operating Procedures (SOPs) and to ensure adherence to SOPs, staff in both countries will be trained prior to commencement of study activity (see Admin Core). Data provided through the activities of Core A are the clinical nexus for all projects, as Core A will provide clinical endpoint triggers to Core B for follow-up. The longitudinal phenotypic data provided by Core A about ASPREE-XT participants will also be of vital importance for addressing the overall aims of this U19 through completion of Project analyzes. Specifically, the collection of information related to cancer screening, cancer incidence, progression, and outcomes are crucial for Project 1 (Cancer). Collection of cognitive data, depression and dementia endpoints are essential for assessing dementia and mild cognitive impairment outcomes in Project 2 (Dementia). Basic activities of daily living, physical function, exhaustion and physical activity data will be collected for assessment of disability and frailty for Project 3 (Disability). Consequently, the success of the U19 hinges upon the data that will be collected as part of this Core. 0