快速绘制 SARS-CoV-2 耐药性图谱的通用无病毒平台-猫眼课题宝

快速绘制 SARS-CoV-2 耐药性图谱的通用无病毒平台

批准号：

10436978

负责人：

Amit Choudhary

金额：

$19.5万

依托单位：

BROAD INSTITUTE, INC.

依托单位国家：

美国

项目类别：

财政年份：

2021

资助国家：

美国

项目状态：

已结题

起止时间：

2021-07-01 至 2024-06-30

来源：

https://reporter.nih.gov/project-details/10436978

关键词：

2019-nCoV 5&apos -exoribonuclease ACE2 Amino Acids Antibodies Antineoplastic Agents Area Bar Codes Binding Biological Assay Biology CASP3 gene COVID-19 Caspase Cell Death Cell Separation Cells Clinical Clustered Regularly Interspaced Short Palindromic Repeats Code Collaborations Development Dose Drug Targeting Drug resistance Drug usage Effectiveness Escape Mutant Ethics Evolution Exploratory/Developmental Grant Fluorescence Future Genotype Guide RNA Hot Spot Laboratories Mammalian Cell Maps Measures Methods Mutagenesis Mutate Mutation Nature Onconase Pancreatic ribonuclease Papain Peptide Hydrolases Pharmaceutical Preparations Polymerase Population Prevalence Proteins RNA RNA-Directed RNA Polymerase Reporter Reporting Research Resistance Resistance development SARS-CoV-2 inhibitor SARS-CoV-2 protease Scheme Shoulder System Technology Testing Therapeutic Agents Universities Viral Viral Proteins Virus Work abuse liability aptamer base coronavirus disease drug candidate drug development drug repurposing inhibitor interest medical schools multidisciplinary mutant neutralizing antibody novel personalized medicine pressure prevent programs remdesivir small molecule stable cell line synthetic biology targeted agent

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中文摘要

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英文摘要

PROJECT SUMMARY Development or repurposing of drugs for SARS-CoV-2 that causes COVID-19 is an active area of research, but not much effort is being spent on developing platforms to identify mutations that may merge to the inhibitors or neutralizing agents for these targets. Given the widespread prevalence of SARS-CoV-2 and potential abuse of developed therapeutic agents, the emergence of such escape mutants is likely. We will develop a virus-free platform to identify and validate escape mutants for therapeutic agents in the pipeline for SARS-CoV-2.

期刊论文(1)

专著(0)

科研奖励(0)

会议论文

Rational Design of Silicon-Based Zinc Ionophores.

DOI： 10.1002/anie.202201698

发表时间： 2022-06-07

期刊：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

影响因子： 16.6

作者：

[Yamada, Kei, Deb, Arghya, Shoba, Veronika M., Lim, Donghyun, Maji, Basudeb, Modell, Ashley E., Choudhary, Amit]